Role of glial amino acid transporters in synaptic transmission and brain energetics - PubMed (original) (raw)
Review
. 2004 Aug 15;47(3):217-225.
doi: 10.1002/glia.20027.
Affiliations
- PMID: 15252810
- DOI: 10.1002/glia.20027
Review
Role of glial amino acid transporters in synaptic transmission and brain energetics
Païkan Marcaggi et al. Glia. 2004.
Abstract
This article reviews how the uptake of neurotransmitter by glial amino acid transporters limits the spatial spread of transmitter to preserve the independent operation of nearby synapses, temporally shapes postsynaptic currents, and regulates the effects of tonic transmitter release. We demonstrate the importance of amino acid uptake and recycling mechanisms for preventing the loss of energetically costly neurotransmitter from the brain, and also examine the suggestion that glutamate uptake into glia plays a key role in regulating the energy production of the brain. Finally, we assess the role of glial amino acid transporters in transmitter recycling pathways.
Copyright 2004 Wiley-Liss, Inc.
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References
REFERENCES
- Armano S, Coco S, Bacci A, Pravettoni E, Schenk U, Verderio C, Varoqui H, Erickson JD, Matteoli M. 2002. Localization and functional relevance of system A neutral amino acid transporters in culture hippocampal neurons. J Biol Chem 277: 19467-10473.
- Arnth-Jensen N, Jabaudon D, Scanziani M. 2002. Cooperation between independent hippocampal synapses is controlled by glutamate uptake. Nat Neurosci 5: 325-331.
- Attwell D, Laughlin SB. 2001. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 21: 1133-1145.
- Attwell D, Barbour B, Szatkowski M. 1993. Nonvesicular release of neurotransmitter. Neuron 11: 401-407.
- Asztély F, Erdemli G, Kullmann DM. 1997. Extrasynaptic glutamate spillover in the hippocampus: dependence on temperature and the role of active glutamate uptake. Neuron 18: 281-293.
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