Recommended diagnostic criteria for paraneoplastic neurological syndromes - PubMed (original) (raw)
. 2004 Aug;75(8):1135-40.
doi: 10.1136/jnnp.2003.034447.
J Y Delattre, J C Antoine, J Dalmau, B Giometto, W Grisold, J Honnorat, P Sillevis Smitt, Ch Vedeler, J J G M Verschuuren, A Vincent, R Voltz
Affiliations
- PMID: 15258215
- PMCID: PMC1739186
- DOI: 10.1136/jnnp.2003.034447
Recommended diagnostic criteria for paraneoplastic neurological syndromes
F Graus et al. J Neurol Neurosurg Psychiatry. 2004 Aug.
Abstract
Background: Paraneoplastic neurological syndromes (PNS) are defined by the presence of cancer and exclusion of other known causes of the neurological symptoms, but this criterion does not separate "true" PNS from neurological syndromes that are coincidental with a cancer.
Objective: To provide more rigorous diagnostic criteria for PNS.
Methods: An international panel of neurologists interested in PNS identified those defined as "classical" in previous studies. The panel reviewed the existing diagnostic criteria and recommended new criteria for those in whom no clinical consensus was reached in the past. The panel reviewed all reported onconeural antibodies and established the conditions to identify those that would be labelled as "well characterised". The antibody information was obtained from published work and from unpublished data from the different laboratories involved in the study.
Results: The panel suggest two levels of evidence to define a neurological syndrome as paraneoplastic: "definite" and "possible". Each level can be reached combining a set of criteria based on the presence or absence of cancer and the definitions of "classical" syndrome and "well characterised" onconeural antibody.
Conclusions: The proposed criteria should help clinicians in the classification of their patients and the prospective and retrospective analysis of PNS cases.
Comment in
- Recommended diagnostic criteria for paraneoplastic neurological syndromes.
Greenlee JE. Greenlee JE. J Neurol Neurosurg Psychiatry. 2004 Aug;75(8):1090. doi: 10.1136/jnnp.2004.038489. J Neurol Neurosurg Psychiatry. 2004. PMID: 15258205 Free PMC article. No abstract available.
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