Eye colour: portals into pigmentation genes and ancestry - PubMed (original) (raw)
Eye colour: portals into pigmentation genes and ancestry
Richard A Sturm et al. Trends Genet. 2004 Aug.
Abstract
Several recent papers have tried to address the genetic determination of eye colour via microsatellite linkage, testing of pigmentation candidate gene polymorphisms and the genome wide analysis of SNP markers that are informative for ancestry. These studies show that the OCA2 gene on chromosome 15 is the major determinant of brown and/or blue eye colour but also indicate that other loci will be involved in the broad range of hues seen in this trait in Europeans.
Similar articles
- Molecular genetics of human pigmentation diversity.
Sturm RA. Sturm RA. Hum Mol Genet. 2009 Apr 15;18(R1):R9-17. doi: 10.1093/hmg/ddp003. Hum Mol Genet. 2009. PMID: 19297406 Review. - Genotype versus phenotype: human pigmentation.
Tully G. Tully G. Forensic Sci Int Genet. 2007 Jun;1(2):105-10. doi: 10.1016/j.fsigen.2007.01.005. Epub 2007 Mar 1. Forensic Sci Int Genet. 2007. PMID: 19083738 - Novel quantitative pigmentation phenotyping enhances genetic association, epistasis, and prediction of human eye colour.
Wollstein A, Walsh S, Liu F, Chakravarthy U, Rahu M, Seland JH, Soubrane G, Tomazzoli L, Topouzis F, Vingerling JR, Vioque J, Böhringer S, Fletcher AE, Kayser M. Wollstein A, et al. Sci Rep. 2017 Feb 27;7:43359. doi: 10.1038/srep43359. Sci Rep. 2017. PMID: 28240252 Free PMC article. - Association of polymorphic sites in the OCA2 gene with eye colour using the tree scanning method.
Branicki W, Brudnik U, Kupiec T, Wolańska-Nowak P, Szczerbińska A, Wojas-Pelc A. Branicki W, et al. Ann Hum Genet. 2008 Mar;72(Pt 2):184-92. doi: 10.1111/j.1469-1809.2007.00407.x. Epub 2007 Dec 18. Ann Hum Genet. 2008. PMID: 18093281 - Genetics of human iris colour and patterns.
Sturm RA, Larsson M. Sturm RA, et al. Pigment Cell Melanoma Res. 2009 Oct;22(5):544-62. doi: 10.1111/j.1755-148X.2009.00606.x. Epub 2009 Jul 8. Pigment Cell Melanoma Res. 2009. PMID: 19619260 Review.
Cited by
- Biogeographic Ancestry in the African Descent and Glaucoma Evaluation Study (ADAGES): Association With Corneal and Optic Nerve Structure.
Girkin CA, Nievergelt CM, Kuo JZ, Maihofer AX, Huisingh C, Liebmann JM, Ayyagari R, Weinreb RN, Ritch R, Zangwill LM; ADAGES Study Group. Girkin CA, et al. Invest Ophthalmol Vis Sci. 2015 Mar 5;56(3):2043-9. doi: 10.1167/iovs.14-15719. Invest Ophthalmol Vis Sci. 2015. PMID: 25744975 Free PMC article. - STRs vs. SNPs: thoughts on the future of forensic DNA testing.
Butler JM, Coble MD, Vallone PM. Butler JM, et al. Forensic Sci Med Pathol. 2007 Sep;3(3):200-5. doi: 10.1007/s12024-007-0018-1. Epub 2007 Sep 12. Forensic Sci Med Pathol. 2007. PMID: 25869164 - The genetic and evolutionary basis of colour variation in vertebrates.
Hofreiter M, Schöneberg T. Hofreiter M, et al. Cell Mol Life Sci. 2010 Aug;67(15):2591-603. doi: 10.1007/s00018-010-0333-7. Epub 2010 Mar 14. Cell Mol Life Sci. 2010. PMID: 20229234 Free PMC article. Review. - Forensic DNA Phenotyping: Genes and Genetic Variants for Eye Color Prediction.
Brancato D, Coniglio E, Bruno F, Agostini V, Saccone S, Federico C. Brancato D, et al. Genes (Basel). 2023 Aug 10;14(8):1604. doi: 10.3390/genes14081604. Genes (Basel). 2023. PMID: 37628655 Free PMC article. Review. - A novel mutation of the StAR gene with congenital adrenal hyperplasia and its association with heterochromia iridis: a case report.
Splittstösser V, Schreiner F, Gohlke B, Welzel M, Holterhus PM, Woelfle J. Splittstösser V, et al. BMC Endocr Disord. 2019 Oct 30;19(1):116. doi: 10.1186/s12902-019-0448-2. BMC Endocr Disord. 2019. PMID: 31666050 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases