Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus - PubMed (original) (raw)
Comparative Study
. 2004 Aug;186(15):5147-52.
doi: 10.1128/JB.186.15.5147-5152.2004.
Zongzhong Tong, Yajun Song, Yanping Han, Decui Pei, Xin Pang, Junhui Zhai, Min Li, Baizhong Cui, Zhizhen Qi, Lixia Jin, Ruixia Dai, Zongmin Du, Jin Wang, Zhaobiao Guo, Jian Wang, Peitang Huang, Ruifu Yang
Affiliations
- PMID: 15262951
- PMCID: PMC451627
- DOI: 10.1128/JB.186.15.5147-5152.2004
Comparative Study
Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus
Dongsheng Zhou et al. J Bacteriol. 2004 Aug.
Abstract
Yersinia pestis has been historically divided into three biovars: antiqua, mediaevalis, and orientalis. On the basis of this study, strains from Microtus-related plague foci are proposed to constitute a new biovar, microtus. Based on the ability to ferment glycerol and arabinose and to reduce nitrate, Y. pestis strains can be assigned to one of four biovars: antiqua (glycerol positive, arabinose positive, and nitrate positive), mediaevalis (glycerol positive, arabinose positive, and nitrate negative), orientalis (glycerol negative, arabinose positive, and nitrate positive), and microtus (glycerol positive, arabinose negative, and nitrate negative). A 93-bp in-frame deletion in glpD gene results in the glycerol-negative characteristic of biovar orientalis strains. Two kinds of point mutations in the napA gene may cause the nitrate reduction-negative characteristic in biovars mediaevalis and microtus, respectively. A 122-bp frameshift deletion in the araC gene may lead to the arabinose-negative phenotype of biovar microtus strains. Biovar microtus strains have a unique genomic profile of gene loss and pseudogene distribution, which most likely accounts for the human attenuation of this new biovar. Focused, hypothesis-based investigations on these specific genes will help delineate the determinants that enable this deadly pathogen to be virulent to humans and give insight into the evolution of Y. pestis and plague pathogenesis. Moreover, there may be the implications for development of biovar microtus strains as a potential vaccine.
Figures
FIG. 1.
Graphic representation of the primer locations in genes glpD (a), napA (b), and araC (c).
Similar articles
- Identification of different regions among strains of Yersinia pestis by suppression subtractive hybridization.
Dai E, Tong Z, Wang X, Li M, Cui B, Dai R, Zhou D, Pei D, Song Y, Zhang J, Li B, Yang J, Chen Z, Guo Z, Wang J, Zhai J, Yang R. Dai E, et al. Res Microbiol. 2005 Aug;156(7):785-9. doi: 10.1016/j.resmic.2005.02.012. Res Microbiol. 2005. PMID: 15993571 - Genetic variability of Yersinia pestis isolates as predicted by PCR-based IS100 genotyping and analysis of structural genes encoding glycerol-3-phosphate dehydrogenase (glpD).
Motin VL, Georgescu AM, Elliott JM, Hu P, Worsham PL, Ott LL, Slezak TR, Sokhansanj BA, Regala WM, Brubaker RR, Garcia E. Motin VL, et al. J Bacteriol. 2002 Feb;184(4):1019-27. doi: 10.1128/jb.184.4.1019-1027.2002. J Bacteriol. 2002. PMID: 11807062 Free PMC article. - Genotyping of Indian Yersinia pestis strains by MLVA and repetitive DNA sequence based PCRs.
Kingston JJ, Tuteja U, Kapil M, Murali HS, Batra HV. Kingston JJ, et al. Antonie Van Leeuwenhoek. 2009 Oct;96(3):303-12. doi: 10.1007/s10482-009-9347-2. Epub 2009 May 16. Antonie Van Leeuwenhoek. 2009. PMID: 19449123 - Plague in the genomic area.
Drancourt M. Drancourt M. Clin Microbiol Infect. 2012 Mar;18(3):224-30. doi: 10.1111/j.1469-0691.2012.03774.x. Clin Microbiol Infect. 2012. PMID: 22369155 Review. - [Plague in Zaire].
Janssens PG, Pattyn SR. Janssens PG, et al. Verh K Acad Geneeskd Belg. 1994;56(4):281-360; discussion 360-1. Verh K Acad Geneeskd Belg. 1994. PMID: 7801703 Review. Dutch.
Cited by
- Development and evaluation of a multi-target droplet digital PCR assay for highly sensitive and specific detection of Yersinia pestis.
Zhao Y, Yan Z, Song K, Li Y, Shen L, Cui Y, Du Z, Yang R, Song Y, Jing L, Zhao Y. Zhao Y, et al. PLoS Negl Trop Dis. 2024 May 3;18(5):e0012167. doi: 10.1371/journal.pntd.0012167. eCollection 2024 May. PLoS Negl Trop Dis. 2024. PMID: 38701065 Free PMC article. - The Natural and Clinical History of Plague: From the Ancient Pandemics to Modern Insights.
Bennasar-Figueras A. Bennasar-Figueras A. Microorganisms. 2024 Jan 11;12(1):146. doi: 10.3390/microorganisms12010146. Microorganisms. 2024. PMID: 38257973 Free PMC article. Review. - Yersinia pestis and Plague: some knowns and unknowns.
Yang R, Atkinson S, Chen Z, Cui Y, Du Z, Han Y, Sebbane F, Slavin P, Song Y, Yan Y, Wu Y, Xu L, Zhang C, Zhang Y, Hinnebusch BJ, Stenseth NC, Motin VL. Yang R, et al. Zoonoses (Burlingt). 2023;3(1):5. doi: 10.15212/zoonoses-2022-0040. Epub 2023 Jan 19. Zoonoses (Burlingt). 2023. PMID: 37602146 Free PMC article. - Comparative Lysine Acetylome Analysis of Y. pestis YfiQ/CobB Mutants Reveals that Acetylation of SlyA Lys73 Significantly Promotes Biofilm Formation of Y. pestis.
Tan Y, Liu W, Chen Y, Zhou Y, Song K, Cao S, Zhang Y, Song Y, Deng H, Yang R, Du Z. Tan Y, et al. Microbiol Spectr. 2023 Aug 17;11(4):e0046023. doi: 10.1128/spectrum.00460-23. Epub 2023 Jul 17. Microbiol Spectr. 2023. PMID: 37458592 Free PMC article. - Transcriptional Regulation of hmsB, A Temperature-Dependent Small RNA, by RovM in Yersinia pestis Biovar Microtus.
Liu L, Liu W, He Y, Liu Y, Wu H, Zhang Y, Zhang Q. Liu L, et al. Curr Microbiol. 2023 Apr 13;80(5):182. doi: 10.1007/s00284-023-03293-1. Curr Microbiol. 2023. PMID: 37046126
References
- Deng, W., V. Burland, G. Plunkett, A. Boutin, G. F. Mayhew, P. Liss, N. T. Perna, D. J. Rose, B. Mau, S. Zhou, D. C. Schwartz, J. D. Fetherston, L. E. Lindler, R. R. Brubaker, G. V Plano, S. C. Straley, K. A. McDonough, M. L. Nilles, J. S. Matson, F. R. Blattner, and R. D. Perry. 2002. Genome sequence of Yersinia pestis KIM. J. Bacteriol. 184:4601-4611. - PMC - PubMed
- Dias, J. M., M. E. Than, A. Humm, R. Huber, G. P. Bourenkov, and H. D. Bartunik. 1999. Crystal structure of the first dissimilatory nitrate reductase at 1.9 Å solved by MAD methods. Struct. Fold Des. 7:65-79. - PubMed
- Fan, Z., Y. Luo, S. Wang, L. Jin, X. Zhou, J. Liu, Y. Zhang, and F. Li. 1995. Microtus brandti plague in the Xilin Gol Grassland was inoffensive to humans. Chin. J. Control Endem. Dis. 10:56-57. (In Chinese.)
- Liu, Z., R. Hai, and F. Li. 2001. The discovery and study of Microtus fuscus natural plague foci in Qinghai-Tibet plateau. Chin. J. Control Endem. Dis. 16:321-327. (In Chinese.)
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous