14-3-3 proteins: a number of functions for a numbered protein - PubMed (original) (raw)
Review
. 2004 Jul 13;2004(242):re10.
doi: 10.1126/stke.2422004re10.
Affiliations
- PMID: 15266103
- DOI: 10.1126/stke.2422004re10
Review
14-3-3 proteins: a number of functions for a numbered protein
Dave Bridges et al. Sci STKE. 2004.
Abstract
Many signal transduction events are orchestrated by specific interactions of proteins mediated through discrete phosphopeptide-binding motifs. Although several phosphospecific-binding domains are now known, 14-3-3s were the first proteins recognized to specifically bind a discrete phosphoserine or phosphothreonine motif. The 14-3-3 proteins are a family of ubiquitously expressed, exclusively eukaryotic proteins with an astonishingly large number of binding partners. Consequently, 14-3-3s modulate an enormous and diverse group of cellular processes. The effects of 14-3-3 proteins on their targets can be broadly defined using three categories: (i) conformational change; (ii) physical occlusion of sequence-specific or structural protein features; and (iii) scaffolding. This review will describe the current state of knowledge on 14-3-3 proteins, highlighting several important advances, and will attempt to provide a framework by which 14-3-3 functions can be understood.
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