Milestones of neuronal development in the adult hippocampus - PubMed (original) (raw)

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Milestones of neuronal development in the adult hippocampus

Gerd Kempermann et al. Trends Neurosci. 2004 Aug.

Abstract

Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus and results in new granule cell neurons. We propose a model of the development that takes place between these two fixed points and identify several developmental milestones. From a presumably bipotent radial-glia-like stem cell (type-1 cell) with astrocytic properties, development progresses over at least two stages of amplifying lineage-determined progenitor cells (type-2 and type-3 cells) to early postmitotic and to mature neurons. The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development.

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