CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid - PubMed (original) (raw)

CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid

V Miriagou et al. Antimicrob Agents Chemother. 2004 Aug.

Abstract

An IncN plasmid (p541) from Escherichia coli carried a Citrobacter freundii-derived sequence of 4,252 bp which included an ampC-ampR region and was bound by two directly repeated IS26 elements. ampC encoded a novel cephalosporinase (CMY-13) with activity similar to that of CMY-2. AmpR was likely functional as indicated in induction experiments.

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Figures

FIG. 1.

Schematic representation of the HindIII-PvuII fragment of plasmid p541 including a C. freundii chromosomal fragment encompassed by IS_26_ elements. Arrows indicate the direction of transcription. This structure is included in the sequence presented for GenBank accession no. AY339625. ITRR, right ITR; ITRL, left ITR.

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