Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries - PubMed (original) (raw)
Review
Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries
Etienne Pays et al. Curr Opin Microbiol. 2004 Aug.
Abstract
Antigenic variation allows African trypanosomes to develop chronic infections in mammalian hosts. This process results from the alternative occurrence of transcriptional switching and DNA recombination targeted to a telomeric locus that contains the gene of the variant antigen and is subjected to mono-allelic expression control. So far, the identification of mechanisms and factors involved still resists technological developments and genome sequencing.
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