Prefrontal neurons coding suppression of specific saccades - PubMed (original) (raw)
Comparative Study
. 2004 Aug 5;43(3):415-25.
doi: 10.1016/j.neuron.2004.07.013.
Affiliations
- PMID: 15294148
- DOI: 10.1016/j.neuron.2004.07.013
Free article
Comparative Study
Prefrontal neurons coding suppression of specific saccades
Ryohei P Hasegawa et al. Neuron. 2004.
Free article
Abstract
The prefrontal cortex has been implicated in the suppression of unwanted behavior, based upon observations of humans and monkeys with prefrontal lesions. Despite this, there has been little direct neurophysiological evidence for a mechanism that suppresses specific behavior. In this study, we used an oculomotor delayed match/nonmatch-to-sample task in which monkeys had to remember a stimulus location either as a marker of where to look or as a marker of where not to look. We found a group of neurons in both the frontal eye field and the caudal prefrontal cortex that carried signals selective for the forbidden stimulus. The activity of these "don't look" neurons correlated with the monkeys' success or failure on the task. These results demonstrate a frontal signal that is related to the active suppression of one action while the subject performs another.
Copyright 2004 Cell Press
Comment in
- Don't go there.
Snyder LH, Lawrence BM. Snyder LH, et al. Neuron. 2004 Aug 5;43(3):297-9. doi: 10.1016/j.neuron.2004.07.021. Neuron. 2004. PMID: 15294137 Review.
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