Circulating hematopoietic progenitors with T lineage potential - PubMed (original) (raw)
Comparative Study
doi: 10.1038/ni1101. Epub 2004 Aug 1.
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- PMID: 15300246
- DOI: 10.1038/ni1101
Comparative Study
Circulating hematopoietic progenitors with T lineage potential
Benjamin A Schwarz et al. Nat Immunol. 2004 Sep.
Abstract
The thymus is seeded via the blood, but the identity of hematopoietic progenitors with access to the circulation in adult mice is unknown. We report here that the only progenitors in blood with efficient T lineage potential were lineage negative with high expression of stem cell antigen 1 and c-Kit (LSK cells). The blood LSK population, like its counterpart in the bone marrow, contained hematopoietic stem cells and nonrenewing, multipotent progenitors, including early lymphoid progenitors and CD62L(+) cells previously described as efficient T lineage progenitors. Common lymphoid progenitors could not be identified in the circulation, suggesting they are not physiological T lineage precursors. We conclude that blood LSK cells are the principal circulating progenitors with T lineage potential.
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