Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages - PubMed (original) (raw)

. 2004 Dec 15;104(13):4038-45.

doi: 10.1182/blood-2004-03-1140. Epub 2004 Aug 10.

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• PMID: 15304394
• DOI: 10.1182/blood-2004-03-1140

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Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages

Jurgen Herre et al. Blood. 2004.

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Abstract

The phagocytosis of pathogens is a critical event in host defense, not only for clearance of the invading microorganism, but also for the subsequent immune response. We have examined Dectin-1, a proinflammatory nonopsonic receptor for beta-glucans, and show that it mediates the internalization of beta-glucan-bearing ligands, including yeast particles. Although requiring tyrosine phosphorylation and the cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM)-like motif, uptake mediated by Dectin-1 was different from any previously reported phagocytic receptor and was not dependent on Syk-kinase in macrophages. Furthermore, intracellular trafficking of this receptor was influenced by the nature of the beta-glucan ligand, which has significance for the biologic activity of these immunomodulatory carbohydrates.

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