Hydroxylation of HIF-1: oxygen sensing at the molecular level - PubMed (original) (raw)
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Hydroxylation of HIF-1: oxygen sensing at the molecular level
Gregg L Semenza. Physiology (Bethesda). 2004 Aug.
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Abstract
The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression.
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