Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection - PubMed (original) (raw)

. 2004 Aug 13;305(5686):1003-6.

doi: 10.1126/science.1099250.

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• PMID: 15310903
• DOI: 10.1126/science.1099250

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Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection

Masatomo Kawakubo et al. Science. 2004.

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Abstract

Helicobacter pylori infects the stomachs of nearly a half the human population, yet most infected individuals remain asymptomatic, which suggests that there is a host defense against this bacterium. Because H. pylori is rarely found in deeper portions of the gastric mucosa, where O-glycans are expressed that have terminal alpha1,4-linked N-acetylglucosamine, we tested whether these O-glycans might affect H. pylori growth. Here, we report that these O-glycans have antimicrobial activity against H. pylori, inhibiting its biosynthesis of cholesteryl-alpha-D-glucopyranoside, a major cell wall component. Thus, the unique O-glycans in gastric mucin appeared to function as a natural antibiotic, protecting the host from H. pylori infection.

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