Intracellular magnesium and insulin resistance - PubMed (original) (raw)
Affiliations
- PMID: 15319146
Free article
Review
Intracellular magnesium and insulin resistance
Junji Takaya et al. Magnes Res. 2004 Jun.
Free article
Abstract
Magnesium, the second most abundant intracellular divalent cation, is a cofactor of many enzymes involved in glucose metabolism. Magnesium has an important role in insulin action, and insulin stimulates magnesium uptake in insulin-sensitive tissues. Impaired biological responses to insulin is referred to as insulin resistance. This review was designed to reach a better understanding of the mechanism involved in the correlation between magnesium and insulin resistance. Intracellular magnesium concentration is low in type 2 diabetes mellitus and in hypertensive patients. In patients with type 2 diabetes an inverse association exists between the plasma magnesium and insulin resistance due to intracellular changes. The suppressed intracellular magnesium concentration may result in defective tyrosine kinase activity and modify insulin sensitivity by influencing receptor activity after binding or by influencing intracellular signaling and processing. Intracellular magnesium deficiency may affect the development of insulin resistance and alter the glucose entry into the cell.
Conclusions: Magnesium is required for both proper glucose utilization and insulin signaling. Metabolic alterations in cellular magnesium, which may play the role of a second messenger for insulin action, contribute to insulin resistance.
Similar articles
- Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance.
Barbagallo M, Dominguez LJ. Barbagallo M, et al. Arch Biochem Biophys. 2007 Feb 1;458(1):40-7. doi: 10.1016/j.abb.2006.05.007. Epub 2006 Jun 12. Arch Biochem Biophys. 2007. PMID: 16808892 Review. - Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium.
Paolisso G, Barbagallo M. Paolisso G, et al. Am J Hypertens. 1997 Mar;10(3):346-55. doi: 10.1016/s0895-7061(96)00342-1. Am J Hypertens. 1997. PMID: 9056694 Review. - Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X.
Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo' A, Paolisso G. Barbagallo M, et al. Mol Aspects Med. 2003 Feb-Jun;24(1-3):39-52. doi: 10.1016/s0098-2997(02)00090-0. Mol Aspects Med. 2003. PMID: 12537988 Review. - Magnesium and glucose homeostasis.
Paolisso G, Scheen A, D'Onofrio F, Lefèbvre P. Paolisso G, et al. Diabetologia. 1990 Sep;33(9):511-4. doi: 10.1007/BF00404136. Diabetologia. 1990. PMID: 2253826 Review.
Cited by
- Nutrient patterns in relation to insulin resistance and endothelial dysfunction in Iranian women.
Dehghani F, Hajhashemy Z, Keshteli AH, Yazdannik A, Falahi E, Saneei P, Esmaillzadeh A. Dehghani F, et al. Sci Rep. 2024 Feb 3;14(1):2857. doi: 10.1038/s41598-024-53263-1. Sci Rep. 2024. PMID: 38310135 Free PMC article. - The Association Between Fasting Blood Sugar and Index of Nutritional Quality in Adult Women.
Alami F, Mohseni GK, Ahmadzadeh M, Vahid F, Gholamalizadeh M, Masoumvand M, Shekari S, Alizadeh A, Shafaei H, Doaei S. Alami F, et al. Front Nutr. 2022 Jun 24;9:883672. doi: 10.3389/fnut.2022.883672. eCollection 2022. Front Nutr. 2022. PMID: 35811985 Free PMC article. - Magnesium status in patients with Type 2 diabetes (about 170 cases).
Salhi H, El Ouahabi H. Salhi H, et al. Ann Afr Med. 2021 Jan-Mar;20(1):64-68. doi: 10.4103/aam.aam_49_19. Ann Afr Med. 2021. PMID: 33727515 Free PMC article. - Unraveling the Mechanisms of Magnesium Supplementation in Alleviating Chronic Kidney Disease Complications and Progression: Balancing Risks and Benefits.
Sadeghpour M, Bejani A, Kupaei MH, Majd SJA, Najafi A, Fakhari S, Abdolizadeh A, Mohammadi K. Sadeghpour M, et al. Biol Trace Elem Res. 2024 Sep 10. doi: 10.1007/s12011-024-04368-1. Online ahead of print. Biol Trace Elem Res. 2024. PMID: 39256329 Review. - Association of dietary magnesium intake and glycohemoglobin with mortality risk in diabetic patients.
Wang HW, Huang YT, Jiang MY. Wang HW, et al. PLoS One. 2022 Dec 28;17(12):e0277180. doi: 10.1371/journal.pone.0277180. eCollection 2022. PLoS One. 2022. PMID: 36576930 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical