The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer - PubMed (original) (raw)
Comparative Study
doi: 10.1038/nm1095. Epub 2004 Aug 22.
María Jesús Larriba, José Miguel García, Paloma Ordóñez-Morán, Cristina Peña, Sandra Peiró, Isabel Puig, Rufo Rodríguez, Ricardo de la Fuente, Antonio Bernad, Marina Pollán, Félix Bonilla, Carlos Gamallo, Antonio García de Herreros, Alberto Muñoz
Affiliations
- PMID: 15322538
- DOI: 10.1038/nm1095
Comparative Study
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
Héctor G Pálmer et al. Nat Med. 2004 Sep.
Abstract
Several non-hypercalcemic analogs of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)(2)D(3)) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognosis but is lost during tumor progression. We show that the SNAIL transcription factor represses VDR gene expression in human colon cancer cells and blocks the antitumor action of EB1089, a 1,25(OH)(2)D(3) analog, in xenografted mice. In human colon cancers, elevated SNAIL expression correlates with downregulation of VDR.
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