Presence of apolipoprotein E epsilon4 allele predisposes to early onset of primary Sjogren's syndrome - PubMed (original) (raw)
. 2004 Dec;43(12):1484-7.
doi: 10.1093/rheumatology/keh383. Epub 2004 Aug 24.
Affiliations
- PMID: 15328426
- DOI: 10.1093/rheumatology/keh383
Presence of apolipoprotein E epsilon4 allele predisposes to early onset of primary Sjogren's syndrome
M Pertovaara et al. Rheumatology (Oxford). 2004 Dec.
Abstract
Background: Apolipoprotein E (apoE) polymorphism plays a central role in lipid metabolism, but has recently also been suggested to regulate inflammation, as judged by levels of serum C-reactive protein (CRP).
Objective: To establish whether polymorphism of the apoE genes affects susceptibility to primary Sjogren's syndrome (pSS), degree of inflammation or age of onset of pSS.
Methods: ApoE genotype distribution and allelic frequencies were analysed using PCR and the TaqMan system in 63 Finnish Caucasian patients with pSS and in 64 healthy controls matched for sex, ethnic origin and area of residence. The clinical and immunological data on the pSS patients were analysed in relation to the apoE genotypes.
Results: There was no difference between pSS patients and controls in apoE genotype and allelic frequencies. The apoE epsilon4 allele was significantly associated with early onset of pSS in the entire population and in female patients (Kaplan-Meier log rank test, P = 0.0407 and P = 0.0168, respectively). The average age (+/- S.D.) of onset of pSS in all apoE epsilon4 allele carriers was 46 +/- 12 and in other genotypes it was 53 +/- 10 yr (P = 0.031, t-test). ApoE polymorphism was not associated with signs of inflammation evaluated by such markers as concentration of plasma CRP, plasma interleukin-6, plasma TNF-alpha, immunoglobulin G and haemoglobin, or leucocyte count or ESR.
Conclusions: ApoE polymorphism does not affect susceptibility to pSS or levels of plasma inflammatory indices in patients with pSS. However, a clear association prevails between apoE epsilon4 and early onset of pSS.
Similar articles
- Immunoglobulin KM and GM gene polymorphisms modify the clinical presentation of primary Sjögren's syndrome.
Pertovaara M, Hurme M, Antonen J, Pasternack A, Pandey JP. Pertovaara M, et al. J Rheumatol. 2004 Nov;31(11):2175-80. J Rheumatol. 2004. PMID: 15517630 - Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome.
Hulkkonen J, Pertovaara M, Antonen J, Pasternack A, Hurme M, Pöllänen P, Lehtimäki T. Hulkkonen J, et al. Rheumatology (Oxford). 2004 Dec;43(12):1476-9. doi: 10.1093/rheumatology/keh369. Epub 2004 Aug 17. Rheumatology (Oxford). 2004. PMID: 15316122 - Association between apolipoprotein E polymorphism and Alzheimer disease in Tehran, Iran.
Raygani AV, Zahrai M, Raygani AV, Doosti M, Javadi E, Rezaei M, Pourmotabbed T. Raygani AV, et al. Neurosci Lett. 2005 Feb 25;375(1):1-6. doi: 10.1016/j.neulet.2004.10.073. Epub 2004 Nov 26. Neurosci Lett. 2005. PMID: 15664112 - Interleukin 6-174 G/C promoter gene polymorphism and sporadic Alzheimer's disease: geographic allele and genotype variations in Europe.
Capurso C, Solfrizzi V, D'Introno A, Colacicco AM, Capurso SA, Capurso A, Panza F. Capurso C, et al. Exp Gerontol. 2004 Oct;39(10):1567-73. doi: 10.1016/j.exger.2004.07.006. Exp Gerontol. 2004. PMID: 15501028 Review. - Methodological problems in genetic association studies of longevity--the apolipoprotein E gene as an example.
Lewis SJ, Brunner EJ. Lewis SJ, et al. Int J Epidemiol. 2004 Oct;33(5):962-70. doi: 10.1093/ije/dyh214. Epub 2004 Aug 19. Int J Epidemiol. 2004. PMID: 15319409 Review.
Cited by
- Apolipoprotein E gene polymorphism and allele frequencies in the Lebanese population.
Mahfouz RA, Sabbagh AS, Zahed LF, Mahfoud ZR, Kalmoni RF, Otrock ZK, Taher AT, Zaatari GS. Mahfouz RA, et al. Mol Biol Rep. 2006 Jun;33(2):145-9. doi: 10.1007/s11033-006-6260-x. Mol Biol Rep. 2006. PMID: 16817024 - Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjögren's syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse.
Nguyen CQ, Sharma A, She JX, McIndoe RA, Peck AB. Nguyen CQ, et al. Exp Eye Res. 2009 Mar;88(3):398-409. doi: 10.1016/j.exer.2008.10.006. Epub 2008 Oct 18. Exp Eye Res. 2009. PMID: 19103199 Free PMC article. - Peripheral blood gene expression profiling in Sjögren's syndrome.
Emamian ES, Leon JM, Lessard CJ, Grandits M, Baechler EC, Gaffney PM, Segal B, Rhodus NL, Moser KL. Emamian ES, et al. Genes Immun. 2009 Jun;10(4):285-96. doi: 10.1038/gene.2009.20. Epub 2009 Apr 30. Genes Immun. 2009. PMID: 19404300 Free PMC article. - Sjögren's syndrome: an old tale with a new twist.
Lee BH, Tudares MA, Nguyen CQ. Lee BH, et al. Arch Immunol Ther Exp (Warsz). 2009 Jan-Feb;57(1):57-66. doi: 10.1007/s00005-009-0002-4. Epub 2009 Feb 14. Arch Immunol Ther Exp (Warsz). 2009. PMID: 19219532 Free PMC article. Review. - Update on Pathogenesis of Sjogren's Syndrome.
Sandhya P, Kurien BT, Danda D, Scofield RH. Sandhya P, et al. Curr Rheumatol Rev. 2017;13(1):5-22. doi: 10.2174/1573397112666160714164149. Curr Rheumatol Rev. 2017. PMID: 27412602 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous