Apoptosis and genomic instability - PubMed (original) (raw)
Review
doi: 10.1038/nrm1443.
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- PMID: 15340382
- DOI: 10.1038/nrm1443
Review
Apoptosis and genomic instability
Boris Zhivotovsky et al. Nat Rev Mol Cell Biol. 2004 Sep.
Abstract
Genomic instability is intrinsically linked to significant alterations in apoptosis control. Chromosomal and microsatellite instability can cause the inactivation of pro-apoptotic pathways. In addition, the inhibition of apoptosis itself can be permissive for the survival and ongoing division of cells that have failed to repair DNA double-strand breaks, experience telomere dysfunction or are in an abnormal polyploid state. Furthermore, DNA-repair proteins can regulate apoptosis. So, genomic instability and apoptosis are intimately linked phenomena, with important implications for the pathophysiology of cancer.
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