Cancer immunotherapy: moving beyond current vaccines - PubMed (original) (raw)

Comparative Study

Cancer immunotherapy: moving beyond current vaccines

Steven A Rosenberg et al. Nat Med. 2004 Sep.

Abstract

Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on surrogate endpoints than on clinical tumor regression. In our cancer vaccine trials of 440 patients, the objective response rate was low (2.6%), and comparable to the results obtained by others. We consider here results in cancer vaccine trials and highlight alternate strategies that mediate cancer regression in preclinical and clinical models.

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Comment in

• Cancer vaccines: pessimism in check.
  Mocellin S, Mandruzzato S, Bronte V, Marincola FM. Mocellin S, et al. Nat Med. 2004 Dec;10(12):1278-9; author reply 1279-80. doi: 10.1038/nm1204-1278. Nat Med. 2004. PMID: 15580242 No abstract available.
• Cancer vaccines: pessimism in check.
  Timmerman JM, Levy R. Timmerman JM, et al. Nat Med. 2004 Dec;10(12):1279; author reply 1279-80. doi: 10.1038/nm1204-1279a. Nat Med. 2004. PMID: 15682512 No abstract available.

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