Regulation of substance P mRNA expression in human dermal microvascular endothelial cells - PubMed (original) (raw)
Review
. 2004 Jan-Feb;22(3 Suppl 33):S24-7.
Affiliations
- PMID: 15344593
Review
Regulation of substance P mRNA expression in human dermal microvascular endothelial cells
P Milner et al. Clin Exp Rheumatol. 2004 Jan-Feb.
Abstract
Vascular endothelial cells have been identified as a source of substance P (SP) which may act in an autocrine/paracrine fashion to bring about nitric oxide (NO)-dependent vasodilatation and mitogen-induced cell division or immunologic and inflammatory responses. Whilst SP is localised in and released from endothelial cells, an endothelial mRNA expression of SP has not previously been shown. In the present study, mRNA expression of SP in human dermal microvascular endothelial cells is demonstrated using in situ hybridisation techniques with enhancement procedures. Incubation of microvascular endothelial cells with nerve growth factor (NGF) under conditions of increased shear stress increases the mRNA expression and release of SP Endothelin (ET) release is also enhanced. These changes are pertinent to circulatory, events that may occur in Raynaud's phenomenon in systemic sclerosis.
Similar articles
- Human dermal microvascular endothelial cells produce nerve growth factor: implications for wound repair.
Gibran NS, Tamura R, Tsou R, Isik FF. Gibran NS, et al. Shock. 2003 Feb;19(2):127-30. doi: 10.1097/00024382-200302000-00007. Shock. 2003. PMID: 12578120 - Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor.
Xu WP, Mizuno N, Shiba H, Takeda K, Hasegawa N, Yoshimatsu S, Inui T, Ozeki Y, Niitani M, Kawaguchi H, Tsuji K, Kato Y, Kurihara H. Xu WP, et al. J Periodontol. 2006 May;77(5):800-7. doi: 10.1902/jop.2006.050183. J Periodontol. 2006. PMID: 16671871 - VCAM-1 expression on human dermal microvascular endothelial cells is directly and specifically up-regulated by substance P.
Quinlan KL, Song IS, Naik SM, Letran EL, Olerud JE, Bunnett NW, Armstrong CA, Caughman SW, Ansel JC. Quinlan KL, et al. J Immunol. 1999 Feb 1;162(3):1656-61. J Immunol. 1999. PMID: 9973426 - Investigation of the Regulation of Roundabout4 by Hypoxia-Inducible Factor-1α in Microvascular Endothelial Cells.
Tian R, Liu Z, Zhang H, Fang X, Wang C, Qi S, Cheng Y, Su G. Tian R, et al. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2586-94. doi: 10.1167/iovs.14-14409. Invest Ophthalmol Vis Sci. 2015. PMID: 26066603 - Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-α in human dermal microvascular endothelial cells.
Pina-Canseco Mdel S, Páez-Arenas A, Massó F, Pérez-Campos E, Martínez-Cruz R, Hernández-Cruz P, Majluf-Cruz A, Martínez-Cruz M, Pérez-Campos Mayoral L, Pérez-Santiago AD, Zenteno E. Pina-Canseco Mdel S, et al. Folia Histochem Cytobiol. 2012 Oct 8;50(3):407-13. doi: 10.5603/19749. Folia Histochem Cytobiol. 2012. PMID: 23042271
Cited by
- Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders.
Singh RB, Naderi A, Cho W, Ortiz G, Musayeva A, Dohlman TH, Chen Y, Ferrari G, Dana R. Singh RB, et al. Ocul Surf. 2022 Jul;25:142-153. doi: 10.1016/j.jtos.2022.06.007. Epub 2022 Jun 30. Ocul Surf. 2022. PMID: 35779793 Free PMC article. Review. - Neuropeptide substance P and the immune response.
Mashaghi A, Marmalidou A, Tehrani M, Grace PM, Pothoulakis C, Dana R. Mashaghi A, et al. Cell Mol Life Sci. 2016 Nov;73(22):4249-4264. doi: 10.1007/s00018-016-2293-z. Epub 2016 Jun 17. Cell Mol Life Sci. 2016. PMID: 27314883 Free PMC article. Review. - Physiology and Pathophysiology of Itch.
Cevikbas F, Lerner EA. Cevikbas F, et al. Physiol Rev. 2020 Jul 1;100(3):945-982. doi: 10.1152/physrev.00017.2019. Epub 2019 Dec 23. Physiol Rev. 2020. PMID: 31869278 Free PMC article. Review. - Vascular disease in scleroderma.
Wigley FM. Wigley FM. Clin Rev Allergy Immunol. 2009 Jun;36(2-3):150-75. doi: 10.1007/s12016-008-8106-x. Clin Rev Allergy Immunol. 2009. PMID: 19067252 Review. - Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.
Steinhoff MS, von Mentzer B, Geppetti P, Pothoulakis C, Bunnett NW. Steinhoff MS, et al. Physiol Rev. 2014 Jan;94(1):265-301. doi: 10.1152/physrev.00031.2013. Physiol Rev. 2014. PMID: 24382888 Free PMC article. Review.