Checkpoints in ER-associated degradation: excuse me, which way to the proteasome? - PubMed (original) (raw)

Review

Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?

Annette Ahner et al. Trends Cell Biol. 2004 Sep.

Abstract

The failure of secreted proteins to fold results in their retrotranslocation from the endoplasmic reticulum (ER) and degradation by the proteasome in a process called "ER-associated degradation" (ERAD). Two recent studies indicate that ERAD substrates are targeted to different pathways depending on the topology of the substrate and the subcellular location of the misfolded domain.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources