Deficits in long-term retention of learned motor skills in patients with cortical or subcortical degeneration - PubMed (original) (raw)
Comparative Study
Deficits in long-term retention of learned motor skills in patients with cortical or subcortical degeneration
Hiroko Mochizuki-Kawai et al. Neuropsychologia. 2004.
Abstract
We investigated the acquisition and long-term retention of new skills in patients with cortical (Alzheimer's disease, AD) and subcortical (progressive supranuclear palsy, PSP; Parkinson's disease, PD) degeneration. The motor skill task performance of the PD and PSP patients improved with training, but the improvement disappeared within a few months, whereas AD patients retained learned skills for 3-18 months. The results of our experiments show that subcortical dysfunction induces a retention deficit for newly learned motor skills. Our present study suggests that a normal striatum is necessary for the formation of long-lasting motor skills, and that the striatum plays an important role as a motor skill consolidation system.
Copyright 2004 Elsevier Ltd.
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