Family transmission and heritability of externalizing disorders: a twin-family study - PubMed (original) (raw)
Family transmission and heritability of externalizing disorders: a twin-family study
Brian M Hicks et al. Arch Gen Psychiatry. 2004 Sep.
Abstract
Background: Antisocial behavior and substance dependence disorders exact a heavy financial and human cost on society. A better understanding of the mechanisms of familial transmission for these "externalizing" disorders is necessary to better understand their etiology and to help develop intervention strategies.
Objectives: To determine the extent to which the family transmission of externalizing disorders is due to a general vs a disorder-specific vulnerability and, owing to the genetically informative nature of our data, to estimate the heritable vs environmental nature of these transmission effects.
Design: We used structural equation modeling to simultaneously estimate the general and specific transmission effects of 4 externalizing disorders: conduct disorder, adult antisocial behavior, alcohol dependence, and drug dependence.
Setting: Participants were recruited from the community and were interviewed in a university laboratory.
Participants: The sample consisted of 542 families participating in the Minnesota Twin Family Study. All families included 17-year-old twins and their biological mother and father.
Main outcome measures: Symptom counts of conduct disorder, the adult criteria for antisocial personality disorder, alcohol dependence, and drug dependence.
Results: Transmission of a general vulnerability to all the externalizing disorders accounted for most familial resemblance. This general vulnerability was highly heritable (h2 = 0.80). Disorder-specific vulnerabilities were also detected for conduct disorder, alcohol dependence, and drug dependence.
Conclusions: The mechanism underlying the familial transmission of externalizing disorders is primarily a highly heritable general vulnerability. This general vulnerability or common risk factor should be the focus of research regarding the etiology and treatment of externalizing disorders.
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- AA00175/AA/NIAAA NIH HHS/United States
- AA09367/AA/NIAAA NIH HHS/United States
- DA05147/DA/NIDA NIH HHS/United States
- MH17069/MH/NIMH NIH HHS/United States
- MH65137/MH/NIMH NIH HHS/United States