Synovial activation in rheumatoid arthritis - PubMed (original) (raw)
Review
doi: 10.2741/1399.
Affiliations
- PMID: 15353290
- DOI: 10.2741/1399
Review
Synovial activation in rheumatoid arthritis
Caroline Ospelt et al. Front Biosci. 2004.
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease with progressive articular damage. Activated cells of the synovium produce pro-inflammatory and matrix-degrading effector molecules, which maintain the inflammation and lead to the destruction of the involved joints. In addition to macrophages and T- and B-cells, fibroblast-like synoviocytes must be considered key cells in driving the pathological processes. They can be distinguished by their transformed-appearing phenotype and their invasion into adjacent cartilage and bone. Synovial activation is driven by pro-inflammatory cytokines as well as cytokine independent pathways including endogenous retroviral elements and Toll-like receptors (TLR). These pathways are connected by a complex network of autocrine and paracrine acting factors. Another feature of RA synovium is hyperplasia of the lining layer, which results from increased proliferation and decreased apoptosis of synovial fibroblasts. Thanks to new techniques in basic research, novel insights into the cellular and molecular mechanisms of the pathogenesis of RA were gained and led to the development of new, specific therapeutic strategies.
Similar articles
- [Rheumatoid arthritis: new developments in the pathogenesis with special reference to synovial fibroblasts].
Seemayer CA, Distler O, Kuchen S, Müller-Ladner U, Michel BA, Neidhart M, Gay RE, Gay S. Seemayer CA, et al. Z Rheumatol. 2001 Oct;60(5):309-18. doi: 10.1007/s003930170030. Z Rheumatol. 2001. PMID: 11759230 Review. German. - The p53 status in rheumatoid arthritis with focus on fibroblast-like synoviocytes.
Taghadosi M, Adib M, Jamshidi A, Mahmoudi M, Farhadi E. Taghadosi M, et al. Immunol Res. 2021 Jun;69(3):225-238. doi: 10.1007/s12026-021-09202-7. Epub 2021 May 13. Immunol Res. 2021. PMID: 33983569 Review. - Detailed analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: implications for treatment.
van Kuijk AW, Reinders-Blankert P, Smeets TJ, Dijkmans BA, Tak PP. van Kuijk AW, et al. Ann Rheum Dis. 2006 Dec;65(12):1551-7. doi: 10.1136/ard.2005.050963. Epub 2006 May 25. Ann Rheum Dis. 2006. PMID: 16728461 Free PMC article. - The SCID mouse model: novel therapeutic targets - lessons from gene transfer.
Pierer M, Müller-Ladner U, Pap T, Neidhart M, Gay RE, Gay S. Pierer M, et al. Springer Semin Immunopathol. 2003 Aug;25(1):65-78. doi: 10.1007/s00281-003-0126-2. Springer Semin Immunopathol. 2003. PMID: 12904892 Review. - Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile.
Soler Palacios B, Estrada-Capetillo L, Izquierdo E, Criado G, Nieto C, Municio C, González-Alvaro I, Sánchez-Mateos P, Pablos JL, Corbí AL, Puig-Kröger A. Soler Palacios B, et al. J Pathol. 2015 Feb;235(3):515-26. doi: 10.1002/path.4466. Epub 2014 Dec 18. J Pathol. 2015. PMID: 25319955
Cited by
- Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection.
Avila-Trejo AM, Rodríguez-Páez LI, Alcántara-Farfán V, Aguilar-Faisal JL. Avila-Trejo AM, et al. Int J Mol Sci. 2023 Aug 23;24(17):13087. doi: 10.3390/ijms241713087. Int J Mol Sci. 2023. PMID: 37685893 Free PMC article. Review. - Signaling pathways in rheumatoid arthritis: implications for targeted therapy.
Ding Q, Hu W, Wang R, Yang Q, Zhu M, Li M, Cai J, Rose P, Mao J, Zhu YZ. Ding Q, et al. Signal Transduct Target Ther. 2023 Feb 17;8(1):68. doi: 10.1038/s41392-023-01331-9. Signal Transduct Target Ther. 2023. PMID: 36797236 Free PMC article. Review. - The Expression of Non-Coding RNAs and Their Target Molecules in Rheumatoid Arthritis: A Molecular Basis for Rheumatoid Pathogenesis and Its Potential Clinical Applications.
Tsai CY, Hsieh SC, Liu CW, Lu CH, Liao HT, Chen MH, Li KJ, Wu CH, Shen CY, Kuo YM, Yu CL. Tsai CY, et al. Int J Mol Sci. 2021 May 26;22(11):5689. doi: 10.3390/ijms22115689. Int J Mol Sci. 2021. PMID: 34073629 Free PMC article. Review. - Sigesbeckia orientalis L. Extract Alleviated the Collagen Type II-Induced Arthritis Through Inhibiting Multi-Target-Mediated Synovial Hyperplasia and Inflammation.
Linghu KG, Xiong SH, Zhao GD, Zhang T, Xiong W, Zhao M, Shen XC, Xu W, Bian Z, Wang Y, Yu H. Linghu KG, et al. Front Pharmacol. 2020 Aug 28;11:547913. doi: 10.3389/fphar.2020.547913. eCollection 2020. Front Pharmacol. 2020. PMID: 32982752 Free PMC article. - C-Reactive Protein Promotes the Activation of Fibroblast-Like Synoviocytes From Patients With Rheumatoid Arthritis.
Fang Z, Lv J, Wang J, Qin Q, He J, Wang M, Zhou G, Liu G, Zhong F, Zheng Y, Lan HY, Wang Q. Fang Z, et al. Front Immunol. 2020 May 20;11:958. doi: 10.3389/fimmu.2020.00958. eCollection 2020. Front Immunol. 2020. PMID: 32508836 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical