Hierarchy revealed in the specification of three skeletal fates by Sox9 and Runx2 - PubMed (original) (raw)
Comparative Study
. 2004 Oct 1;274(1):188-200.
doi: 10.1016/j.ydbio.2004.07.006.
Affiliations
- PMID: 15355797
- DOI: 10.1016/j.ydbio.2004.07.006
Free article
Comparative Study
Hierarchy revealed in the specification of three skeletal fates by Sox9 and Runx2
B Frank Eames et al. Dev Biol. 2004.
Free article
Abstract
Across vertebrates, there are three principal skeletal tissues: bone, persistent cartilage, and replacement cartilage. Although each tissue has a different evolutionary history and functional morphology, they also share many features. For example, they function as structural supports, they are comprised of cells embedded in collagen-rich extracellular matrix, and they derive from a common embryonic stem cell, the osteochondroprogenitor. Occasionally, homologous skeletal elements can change tissue type through phylogeny. Together, these observations raise the possibility that skeletal tissue identity is determined by a shared set of genes. Here, we show that misexpression of either Sox9 or Runx2 can substitute bone with replacement cartilage or can convert persistent cartilage into replacement cartilage and vice versa. Our data also suggest that these transcription factors function in a molecular hierarchy in which chondrogenic factors dominate. We propose a binary molecular code that determines whether skeletal tissues form as bone, persistent cartilage, or replacement cartilage. Finally, these data provide insights into the roles that master regulatory genes play during evolutionary change of the vertebrate skeleton.
Similar articles
- Possible roles of Runx1 and Sox9 in incipient intramembranous ossification.
Yamashiro T, Wang XP, Li Z, Oya S, Aberg T, Fukunaga T, Kamioka H, Speck NA, Takano-Yamamoto T, Thesleff I. Yamashiro T, et al. J Bone Miner Res. 2004 Oct;19(10):1671-7. doi: 10.1359/JBMR.040801. Epub 2004 Aug 3. J Bone Miner Res. 2004. PMID: 15355562 - Gene expression reveals unique skeletal patterning in the limb of the direct-developing frog, Eleutherodactylus coqui.
Kerney R, Hanken J. Kerney R, et al. Evol Dev. 2008 Jul-Aug;10(4):439-48. doi: 10.1111/j.1525-142X.2008.00255.x. Evol Dev. 2008. PMID: 18638321 - Regulation and role of Sox9 in cartilage formation.
Healy C, Uwanogho D, Sharpe PT. Healy C, et al. Dev Dyn. 1999 May;215(1):69-78. doi: 10.1002/(SICI)1097-0177(199905)215:1<69::AID-DVDY8>3.0.CO;2-N. Dev Dyn. 1999. PMID: 10340758 - The role of TGFbetas and Sox9 during limb chondrogenesis.
Kawakami Y, Rodriguez-León J, Izpisúa Belmonte JC. Kawakami Y, et al. Curr Opin Cell Biol. 2006 Dec;18(6):723-9. doi: 10.1016/j.ceb.2006.10.007. Epub 2006 Oct 16. Curr Opin Cell Biol. 2006. PMID: 17049221 Review. - [Matrix gene regulation in cartilage].
Okazaki K, Iwamoto Y. Okazaki K, et al. Clin Calcium. 2006 Jul;16(7):1213-19. Clin Calcium. 2006. PMID: 16816484 Review. Japanese.
Cited by
- Regulatory role of NFAT1 signaling in articular chondrocyte activities and osteoarthritis pathogenesis.
Zhang M, Campbell T, Falcon S, Wang J. Zhang M, et al. Biocell. 2023;47(10):2125-2132. doi: 10.32604/biocell.2023.030161. Epub 2023 Nov 8. Biocell. 2023. PMID: 37974562 - Come together over me: Cells that form the dermatocranium and chondrocranium in mice.
Pitirri MK, Richtsmeier JT, Kawasaki M, Coupe AP, Perrine SM, Kawasaki K. Pitirri MK, et al. Anat Rec (Hoboken). 2023 Jul 27:10.1002/ar.25295. doi: 10.1002/ar.25295. Online ahead of print. Anat Rec (Hoboken). 2023. PMID: 37497849 - Microenvironmental mechanoactivation through Yap/Taz suppresses chondrogenic gene expression.
Hallström GF, Jones DL, Locke RC, Bonnevie ED, Kim SY, Laforest L, Garcia DC, Mauck RL. Hallström GF, et al. Mol Biol Cell. 2023 Jun 1;34(7):ar73. doi: 10.1091/mbc.E22-12-0543. Epub 2023 Apr 12. Mol Biol Cell. 2023. PMID: 37043309 Free PMC article. - Osteochondrogenesis by TGF-β3, BMP-2 and noggin growth factor combinations in an ex vivo muscle tissue model: Temporal function changes affecting tissue morphogenesis.
Liu H, Müller PE, Aszódi A, Klar RM. Liu H, et al. Front Bioeng Biotechnol. 2023 Mar 16;11:1140118. doi: 10.3389/fbioe.2023.1140118. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 37008034 Free PMC article. - Quantification and comparison of teleost scleral cartilage development and growth.
Zinck NW, Franz-Odendaal TA. Zinck NW, et al. J Anat. 2022 Oct;241(4):1014-1025. doi: 10.1111/joa.13727. Epub 2022 Jul 21. J Anat. 2022. PMID: 36574601 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials