E2F target genes: unraveling the biology - PubMed (original) (raw)
Review
E2F target genes: unraveling the biology
Adrian P Bracken et al. Trends Biochem Sci. 2004 Aug.
Abstract
The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.
Similar articles
- E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints.
Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD. Ren B, et al. Genes Dev. 2002 Jan 15;16(2):245-56. doi: 10.1101/gad.949802. Genes Dev. 2002. PMID: 11799067 Free PMC article. - E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis.
Polager S, Kalma Y, Berkovich E, Ginsberg D. Polager S, et al. Oncogene. 2002 Jan 17;21(3):437-46. doi: 10.1038/sj.onc.1205102. Oncogene. 2002. PMID: 11821956 - Caspase-dependent apoptosis by ectopic expression of E2F-4.
Chang YC, Nakajima H, Illenye S, Lee YS, Honjo N, Makiyama T, Fujiwara I, Mizuta N, Sawai K, Saida K, Mitsui Y, Heintz NH, Magae J. Chang YC, et al. Oncogene. 2000 Sep 28;19(41):4713-20. doi: 10.1038/sj.onc.1203833. Oncogene. 2000. PMID: 11032021 - Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation.
Sidle A, Palaty C, Dirks P, Wiggan O, Kiess M, Gill RM, Wong AK, Hamel PA. Sidle A, et al. Crit Rev Biochem Mol Biol. 1996 Jun;31(3):237-71. doi: 10.3109/10409239609106585. Crit Rev Biochem Mol Biol. 1996. PMID: 8817077 Review. - E2F target genes and cell-cycle checkpoint control.
Lavia P, Jansen-Dürr P. Lavia P, et al. Bioessays. 1999 Mar;21(3):221-30. doi: 10.1002/(SICI)1521-1878(199903)21:3<221::AID-BIES6>3.0.CO;2-J. Bioessays. 1999. PMID: 10333731 Review.
Cited by
- Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation.
Lin JX, Ge M, Liu CY, Holewinski R, Andresson T, Yu ZX, Gebregiorgis T, Spolski R, Li P, Leonard WJ. Lin JX, et al. Nat Commun. 2024 Aug 27;15(1):7372. doi: 10.1038/s41467-024-50925-6. Nat Commun. 2024. PMID: 39191751 Free PMC article. - PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1.
Nakata Y, Nagasawa S, Sera Y, Yamasaki N, Kanai A, Kobatake K, Ueda T, Koizumi M, Manabe I, Kaminuma O, Honda H. Nakata Y, et al. Sci Rep. 2024 Aug 3;14(1):17987. doi: 10.1038/s41598-024-68295-w. Sci Rep. 2024. PMID: 39097652 Free PMC article. - PAX5 functions as a tumor suppressor by RB-E2F-mediated cell cycle arrest in Kaposi sarcoma-associated herpesvirus-infected primary effusion lymphoma.
Goto H, Kariya R, Kudo E, Katano H, Okada S. Goto H, et al. Neoplasia. 2024 Oct;56:101035. doi: 10.1016/j.neo.2024.101035. Epub 2024 Aug 2. Neoplasia. 2024. PMID: 39096792 Free PMC article. - The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2.
Longhurst AD, Wang K, Suresh HG, Ketavarapu M, Ward HN, Jones IR, Narayan V, Hundley FV, Hassan AZ, Boone C, Myers CL, Shen Y, Ramani V, Andrews BJ, Toczyski DP. Longhurst AD, et al. bioRxiv [Preprint]. 2024 Mar 19:2024.03.18.585604. doi: 10.1101/2024.03.18.585604. bioRxiv. 2024. PMID: 38562687 Free PMC article. Preprint. - Give and Take: The Reciprocal Control of Metabolism and Cell Cycle.
Riscal R, Riquier-Morcant B, Gadea G, Linares LK. Riscal R, et al. Methods Mol Biol. 2024;2740:155-168. doi: 10.1007/978-1-0716-3557-5_10. Methods Mol Biol. 2024. PMID: 38393475
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources