Signaling to NF-kappaB - PubMed (original) (raw)
Review
. 2004 Sep 15;18(18):2195-224.
doi: 10.1101/gad.1228704.
Affiliations
- PMID: 15371334
- DOI: 10.1101/gad.1228704
Free article
Review
Signaling to NF-kappaB
Matthew S Hayden et al. Genes Dev. 2004.
Free article
Abstract
The transcription factor NF-kappaB has been the focus of intense investigation for nearly two decades. Over this period, considerable progress has been made in determining the function and regulation of NF-kappaB, although there are nuances in this important signaling pathway that still remain to be understood. The challenge now is to reconcile the regulatory complexity in this pathway with the complexity of responses in which NF-kappaB family members play important roles. In this review, we provide an overview of established NF-kappaB signaling pathways with focus on the current state of research into the mechanisms that regulate IKK activation and NF-kappaB transcriptional activity.
Similar articles
- Regulation and function of IKK and IKK-related kinases.
Häcker H, Karin M. Häcker H, et al. Sci STKE. 2006 Oct 17;2006(357):re13. doi: 10.1126/stke.3572006re13. Sci STKE. 2006. PMID: 17047224 Review. - Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Karin M, Ben-Neriah Y. Karin M, et al. Annu Rev Immunol. 2000;18:621-63. doi: 10.1146/annurev.immunol.18.1.621. Annu Rev Immunol. 2000. PMID: 10837071 Review. - Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation.
Arsura M, Panta GR, Bilyeu JD, Cavin LG, Sovak MA, Oliver AA, Factor V, Heuchel R, Mercurio F, Thorgeirsson SS, Sonenshein GE. Arsura M, et al. Oncogene. 2003 Jan 23;22(3):412-25. doi: 10.1038/sj.onc.1206132. Oncogene. 2003. PMID: 12545162 - NF-kappaB regulation in the immune system.
Li Q, Verma IM. Li Q, et al. Nat Rev Immunol. 2002 Oct;2(10):725-34. doi: 10.1038/nri910. Nat Rev Immunol. 2002. PMID: 12360211 Review. - Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells.
Zhou L, Tan A, Iasvovskaia S, Li J, Lin A, Hershenson MB. Zhou L, et al. Am J Respir Cell Mol Biol. 2003 Jun;28(6):762-9. doi: 10.1165/rcmb.2002-0261OC. Epub 2003 Jan 31. Am J Respir Cell Mol Biol. 2003. PMID: 12600818
Cited by
- O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and Cancer.
Vásquez Martínez IP, Pérez-Campos E, Pérez-Campos Mayoral L, Cruz Luis HI, Pina Canseco MDS, Zenteno E, Bazán Salinas IL, Martínez Cruz M, Pérez-Campos Mayoral E, Hernández-Huerta MT. Vásquez Martínez IP, et al. Int J Mol Sci. 2024 Sep 13;25(18):9896. doi: 10.3390/ijms25189896. Int J Mol Sci. 2024. PMID: 39337387 Free PMC article. Review. - Pathogenic Mechanisms That May Link Periodontal Disease and Type 2 Diabetes Mellitus-The Role of Oxidative Stress.
Mirnic J, Djuric M, Brkic S, Gusic I, Stojilkovic M, Tadic A, Veljovic T. Mirnic J, et al. Int J Mol Sci. 2024 Sep 11;25(18):9806. doi: 10.3390/ijms25189806. Int J Mol Sci. 2024. PMID: 39337292 Free PMC article. Review. - NF-κB Transcription Factors: Their Distribution, Family Expansion, Structural Conservation, and Evolution in Animals.
Msweli S, Pakala SB, Syed K. Msweli S, et al. Int J Mol Sci. 2024 Sep 10;25(18):9793. doi: 10.3390/ijms25189793. Int J Mol Sci. 2024. PMID: 39337282 Free PMC article. - Combined intestinal microbiota and transcriptomic analysis to investigate the effect of different stocking densities on the ability of Pacific white shrimp (Litopenaeus vannamei) to utilize Chlorella sorokiniana.
Yuan H, Xie M, Chen J, Hu N, Wang H, Tan B, Shi L, Zhang S. Yuan H, et al. Anim Nutr. 2024 Apr 26;18:203-219. doi: 10.1016/j.aninu.2024.04.008. eCollection 2024 Sep. Anim Nutr. 2024. PMID: 39281052 Free PMC article. - Novel Anti-Cancer Stem Cell Compounds: A Comprehensive Review.
Guo S, Zheng S, Liu M, Wang G. Guo S, et al. Pharmaceutics. 2024 Aug 1;16(8):1024. doi: 10.3390/pharmaceutics16081024. Pharmaceutics. 2024. PMID: 39204369 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous