The role of RNA interference in heterochromatic silencing - PubMed (original) (raw)
Review
. 2004 Sep 16;431(7006):364-70.
doi: 10.1038/nature02875.
Affiliations
- PMID: 15372044
- DOI: 10.1038/nature02875
Review
The role of RNA interference in heterochromatic silencing
Zachary Lippman et al. Nature. 2004.
Abstract
Soon after its discovery 75 years ago, heterochromatin, a dense chromosomal material, was found to silence genes. But its importance in regulating gene expression was controversial. Long thought to be inert, heterochromatin is now known to give rise to small RNAs, which, by means of RNA interference, direct the modification of proteins and DNA in heterochromatic repeats and transposable elements. Heterochromatin has thus emerged as a key factor in epigenetic regulation of gene expression, chromosome behaviour and evolution.
Similar articles
- Role of transposable elements in heterochromatin and epigenetic control.
Lippman Z, Gendrel AV, Black M, Vaughn MW, Dedhia N, McCombie WR, Lavine K, Mittal V, May B, Kasschau KD, Carrington JC, Doerge RW, Colot V, Martienssen R. Lippman Z, et al. Nature. 2004 Jul 22;430(6998):471-6. doi: 10.1038/nature02651. Nature. 2004. PMID: 15269773 - Heterochromatin and epigenetic control of gene expression.
Grewal SI, Moazed D. Grewal SI, et al. Science. 2003 Aug 8;301(5634):798-802. doi: 10.1126/science.1086887. Science. 2003. PMID: 12907790 Review. - Transcription and RNAi in heterochromatic gene silencing.
Bühler M, Moazed D. Bühler M, et al. Nat Struct Mol Biol. 2007 Nov;14(11):1041-8. doi: 10.1038/nsmb1315. Epub 2007 Nov 5. Nat Struct Mol Biol. 2007. PMID: 17984966 - Slicing and spreading of heterochromatic silencing by RNA interference.
Locke SM, Martienssen RA. Locke SM, et al. Cold Spring Harb Symp Quant Biol. 2006;71:497-503. doi: 10.1101/sqb.2006.71.062. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381332 Review. - [RNA directed DNA elimination in Tetrahymena].
Mochizuki K. Mochizuki K. Tanpakushitsu Kakusan Koso. 2006 Dec;51(16 Suppl):2624-30. Tanpakushitsu Kakusan Koso. 2006. PMID: 17471988 Review. Japanese. No abstract available.
Cited by
- ARID1 is required to regulate and reinforce H3K9me2 in sperm cells in Arabidopsis.
Li L, Yang H, Zhao Y, Hu Q, Zhang X, Jiang T, Jiang H, Zheng B. Li L, et al. Nat Commun. 2024 Aug 16;15(1):7078. doi: 10.1038/s41467-024-51513-4. Nat Commun. 2024. PMID: 39152128 Free PMC article. - Impact of Peptide Sequence on Functional siRNA Delivery and Gene Knockdown with Cyclic Amphipathic Peptide Delivery Agents.
Jagrosse ML, Baliga UK, Jones CW, Russell JJ, García CI, Najar RA, Rahman A, Dean DA, Nilsson BL. Jagrosse ML, et al. Mol Pharm. 2023 Dec 4;20(12):6090-6103. doi: 10.1021/acs.molpharmaceut.3c00455. Epub 2023 Nov 14. Mol Pharm. 2023. PMID: 37963105 Free PMC article. - Synergistic action of the Arabidopsis spliceosome components PRP39a and SmD1b in promoting posttranscriptional transgene silencing.
Bazin J, Elvira-Matelot E, Blein T, Jauvion V, Bouteiller N, Cao J, Crespi MD, Vaucheret H. Bazin J, et al. Plant Cell. 2023 May 29;35(6):1917-1935. doi: 10.1093/plcell/koad091. Plant Cell. 2023. PMID: 36970782 Free PMC article. - Canalization of genome-wide transcriptional activity in Arabidopsis thaliana accessions by MET1-dependent CG methylation.
Srikant T, Yuan W, Berendzen KW, Contreras-Garrido A, Drost HG, Schwab R, Weigel D. Srikant T, et al. Genome Biol. 2022 Dec 20;23(1):263. doi: 10.1186/s13059-022-02833-5. Genome Biol. 2022. PMID: 36539836 Free PMC article. - SMRI: A New Method for siRNA Design for COVID-19 Therapy.
Chen MX, Zhu XD, Zhang H, Liu Z, Liu YN. Chen MX, et al. J Comput Sci Technol. 2022;37(4):991-1002. doi: 10.1007/s11390-021-0826-x. Epub 2022 Jul 30. J Comput Sci Technol. 2022. PMID: 35992496 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases