Cells can use their transferrin receptors for locomotion - PubMed (original) (raw)
Cells can use their transferrin receptors for locomotion
M S Bretscher. EMBO J. 1992 Feb.
Abstract
Cells of the B lymphoblastoid cell line JY attach to substrata made of antibodies to the transferrin receptor. Many of these attached cells migrate considerable distances. JY cells also attach to an anti-integrin substratum (anti LFA-1), but on this surface they do not migrate. These results suggest that a circulating receptor--the transferrin receptor--can be used for locomotory purposes, whereas LFA-1, which is not endocytosed in these cells, cannot be used for locomotion. This indicates that the endocytotic cycle can drive cell locomotion.
References
- Nature. 1976 Mar 4;260(5546):21-3 - PubMed
- Proc Natl Acad Sci U S A. 1980 Jul;77(7):4156-9 - PubMed
- Trends Genet. 1991 May;7(5):161-6 - PubMed
- Annu Rev Cell Biol. 1990;6:359-402 - PubMed
- EMBO J. 1989 May;8(5):1341-8 - PubMed
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