Hitting their targets: an emerging picture of E2F and cell cycle control - PubMed (original) (raw)
Review
Hitting their targets: an emerging picture of E2F and cell cycle control
Alexandre Blais et al. Curr Opin Genet Dev. 2004 Oct.
Abstract
Understanding the role of transcription factors in governing cell-cycle progression in mammalian cells has been hindered until recently by a relative lack of genetic and genomic approaches. New approaches that harness the power of ChIP and combine this technique with DNA microarrays and bioinformatics have identified direct, physiological targets and have significantly altered our view of the E2F transcription factor that is known to play a role in regulation of cell-cycle progression. Further, the identification of additional E2F family members and factors that function in concert with E2F have considerably expanded our picture of the genetic programs that are governed by this essential regulatory factor.
Similar articles
- Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors.
Kel AE, Kel-Margoulis OV, Farnham PJ, Bartley SM, Wingender E, Zhang MQ. Kel AE, et al. J Mol Biol. 2001 May 25;309(1):99-120. doi: 10.1006/jmbi.2001.4650. J Mol Biol. 2001. PMID: 11491305 - Molecular mechanisms of E2F-dependent activation and pRB-mediated repression.
Frolov MV, Dyson NJ. Frolov MV, et al. J Cell Sci. 2004 May 1;117(Pt 11):2173-81. doi: 10.1242/jcs.01227. J Cell Sci. 2004. PMID: 15126619 Review. - ASPP1 and ASPP2 are new transcriptional targets of E2F.
Fogal V, Kartasheva NN, Trigiante G, Llanos S, Yap D, Vousden KH, Lu X. Fogal V, et al. Cell Death Differ. 2005 Apr;12(4):369-76. doi: 10.1038/sj.cdd.4401562. Cell Death Differ. 2005. PMID: 15731768 - Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.
Christensen J, Cloos P, Toftegaard U, Klinkenberg D, Bracken AP, Trinh E, Heeran M, Di Stefano L, Helin K. Christensen J, et al. Nucleic Acids Res. 2005 Sep 22;33(17):5458-70. doi: 10.1093/nar/gki855. Print 2005. Nucleic Acids Res. 2005. PMID: 16179649 Free PMC article. - Life and death decisions by E2F-1.
Bell LA, Ryan KM. Bell LA, et al. Cell Death Differ. 2004 Feb;11(2):137-42. doi: 10.1038/sj.cdd.4401324. Cell Death Differ. 2004. PMID: 14526389 Review.
Cited by
- E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.
Zappia MP, Kwon YJ, Westacott A, Liseth I, Lee HM, Islam ABMMK, Kim J, Frolov MV. Zappia MP, et al. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2220770120. doi: 10.1073/pnas.2220770120. Epub 2023 Apr 3. Proc Natl Acad Sci U S A. 2023. PMID: 37011211 Free PMC article. - Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective.
Coller HA. Coller HA. Compr Physiol. 2019 Dec 18;10(1):317-344. doi: 10.1002/cphy.c190014. Compr Physiol. 2019. PMID: 31853969 Free PMC article. Review. - miR‑145 suppresses ovarian cancer progression via modulation of cell growth and invasion by targeting CCND2 and E2F3.
Hua M, Qin Y, Sheng M, Cui X, Chen W, Zhong J, Yan J, Chen Y. Hua M, et al. Mol Med Rep. 2019 May;19(5):3575-3583. doi: 10.3892/mmr.2019.10004. Epub 2019 Mar 5. Mol Med Rep. 2019. PMID: 30864742 Free PMC article. - Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS.
Jackson DP, Ting JH, Pozniak PD, Meurice C, Schleidt SS, Dao A, Lee AH, Klinman E, Jordan-Sciutto KL. Jackson DP, et al. Mol Cell Neurosci. 2018 Oct;92:1-11. doi: 10.1016/j.mcn.2018.06.003. Epub 2018 Jun 22. Mol Cell Neurosci. 2018. PMID: 29936143 Free PMC article. - Proliferation of vascular smooth muscle cells under inflammation is regulated by NF-κB p65/microRNA-17/RB pathway activation.
Yang D, Sun C, Zhang J, Lin S, Zhao L, Wang L, Lin R, Lv J, Xin S. Yang D, et al. Int J Mol Med. 2018 Jan;41(1):43-50. doi: 10.3892/ijmm.2017.3212. Epub 2017 Oct 25. Int J Mol Med. 2018. PMID: 29115381 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources