Time course of K+ current inhibition by low oxygen in chemoreceptor cells of adult rabbit carotid body. Effects of carbon monoxide - PubMed (original) (raw)
Time course of K+ current inhibition by low oxygen in chemoreceptor cells of adult rabbit carotid body. Effects of carbon monoxide
J R López-López et al. FEBS Lett. 1992.
Free article
Abstract
K+ currents recorded from adult rabbit chemoreceptor cells are reversibly inhibited on lowering the pO2 in the bathing solution. Bath application of a hypoxic TTX-containing solution revealed that inhibition of K+ current by low pO2 proceeds faster than TTX inhibition of Na+ currents, the apparent t1/2 being 3.68 and 7.14 s, respectively. Addition of carbon monoxide to the hypoxic gas mixture used to equilibrate the bathing solution reversed the inhibition of K+ currents by approx. 70%.
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