Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites - PubMed (original) (raw)
. 2004 Oct;10(10):1104-10.
doi: 10.1038/nm1108. Epub 2004 Sep 26.
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- PMID: 15448686
- DOI: 10.1038/nm1108
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Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites
Colby Zaph et al. Nat Med. 2004 Oct.
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Abstract
Infection with Leishmania major induces a protective immune response and long-term resistance to reinfection, which is thought to depend upon persistent parasites. Here we demonstrate that although effector CD4(+) T cells are lost in the absence of parasites, central memory CD4(+) T cells are maintained. Upon secondary infection, these central memory T cells become tissue-homing effector T cells and mediate protection. Thus, immunity to L. major is mediated by at least two distinct populations of CD4(+) T cells: short-lived pathogen-dependent effector cells and long-lived pathogen-independent central memory cells. These data suggest that central memory T cells should be the targets for nonlive vaccines against infectious diseases requiring cell-mediated immunity.
Comment in
- Memory may not need reminding.
Seder RA, Sacks DL. Seder RA, et al. Nat Med. 2004 Oct;10(10):1045-7. doi: 10.1038/nm1004-1045. Nat Med. 2004. PMID: 15459703 No abstract available.
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