LTP and LTD: an embarrassment of riches - PubMed (original) (raw)
Review
. 2004 Sep 30;44(1):5-21.
doi: 10.1016/j.neuron.2004.09.012.
Affiliations
- PMID: 15450156
- DOI: 10.1016/j.neuron.2004.09.012
Free article
Review
LTP and LTD: an embarrassment of riches
Robert C Malenka et al. Neuron. 2004.
Free article
Abstract
LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission, are widespread phenomena expressed at possibly every excitatory synapse in the mammalian brain. It is now clear that "LTP" and "LTD" are not unitary phenomena. Their mechanisms vary depending on the synapses and circuits in which they operate. Here we review those forms of LTP and LTD for which mechanisms have been most firmly established. Examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources