Asymmetry analysis of cingulum based on scale-invariant parameterization by diffusion tensor imaging - PubMed (original) (raw)

Asymmetry analysis of cingulum based on scale-invariant parameterization by diffusion tensor imaging

Gaolang Gong et al. Hum Brain Mapp. 2005 Feb.

Abstract

Current analysis of diffusion tensor imaging (DTI) is based mostly on a region of interest (ROI) in an image dataset, which is specified by users. This method is not always reliable, however, because of the uncertainty of manual specification. We introduce an improved fiber-based scheme rather than an ROI-based analysis to study in DTI datasets of 31 normal subjects the asymmetry of the cingulum, which is one of the most prominent white matter fiber tracts of the limbic system. The present method can automatically extract the quantitative anisotropy properties along the cingulum bundles from tractography. Moreover, statistical analysis was carried out after anatomic correspondence specific to the cingulum across subjects was established, rather than the traditional whole-brain registration. The main merit of our method compared to existing counterparts is that to find such anatomic correspondence in cingulum, a scale-invariant parameterization method by arc-angle was proposed. It can give a continuous and exact description on any segment of cingulum. More interestingly, a significant left-greater-than-right asymmetry pattern was obtained in most segments of cingulum bundle (-50-25 degrees), except in the most posterior portion of cingulum (25-50 degrees).

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Figures

Figure 1

Figure 1

Left: Localizer image showing some parts of scan locations. Baseline denotes the AC–PC line, and the other three parallel lines are parts of scan location. FA map is the middle; at right is the corresponding color‐coded tensor image. All figures came from one subject.

Figure 2

Figure 2

The sketch map for parameterized procedure: The left–right line passing the AC point was assigned as the axis of rotation; Seed plane (S0) denotes the reference plane; sampling plane is denoted by S0, S1, …, S_n_. Cingulum, which was marked by gray, was parameterized by arc angle (θ) in the new polar coordinate system.

Figure 3

Figure 3

A: Reconstruction of the cingulum tracts for one subject is illustrated. Red and white denote anterior and posterior part of cingulum, respectively. B: FA values for left and right side are plotted corresponding to arc angle. For horizontal axis, left to right represent anterior to posterior.

Figure 4

Figure 4

Statistical analysis using repeated measures ANOVA. A: Averaged FA and SD distribution in males; black denotes left and gray denotes right. B: Averaged FA and SD distribution in females; black denoted left and gray denoted right. C: Significance of repeated measures ANOVA by side effect. For horizontal axis, left to right represent anterior to posterior.

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