Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants - PubMed (original) (raw)

Comparative Study

. 1992 Feb 28;255(5048):1134-7.

doi: 10.1126/science.1546316.

Affiliations

• PMID: 1546316
• DOI: 10.1126/science.1546316

Comparative Study

Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants

S M Wolinsky et al. Science. 1992.

Abstract

Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region, present in each mother's sequence set, was absent in all of the infants' sequence sets. These findings demonstrate that a minor subset of maternal virus is transmitted to the infant.

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Comment in

• Infection with selection: HIV in human infants.
  Palca J. Palca J. Science. 1992 Feb 28;255(5048):1069. doi: 10.1126/science.1546308. Science. 1992. PMID: 1546308 No abstract available.

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