Effect of sodium salicylate on the human heat shock response - PubMed (original) (raw)

. 1992 Mar 6;255(5049):1243-5.

doi: 10.1126/science.1546322.

Affiliations

• PMID: 1546322
• DOI: 10.1126/science.1546322

Effect of sodium salicylate on the human heat shock response

D A Jurivich et al. Science. 1992.

Abstract

Sodium salicylate, an anti-inflammatory agent, was examined for its effects on the heat shock response in cultured human cells. Salicylate activation of DNA binding by the heat shock transcription factor (HSF) was comparable to activation attained during heat shock. However, sodium salicylate did not induce heat shock gene transcription even though the HSF was bound in vivo to the heat shock elements upstream of the heat shock protein 70 (Hsp 70) gene. These results reveal that activation of the heat shock transcriptional response is a multistep process. Modulation of extracellular pH augments sensitivity to salicylate-induced activation of HSF.

PubMed Disclaimer

Similar articles

• Salicylate triggers heat shock factor differently than heat.
  Jurivich DA, Pachetti C, Qiu L, Welk JF. Jurivich DA, et al. J Biol Chem. 1995 Oct 13;270(41):24489-95. doi: 10.1074/jbc.270.41.24489. J Biol Chem. 1995. PMID: 7592665
• Sodium salicylate decreases intracellular ATP, induces both heat shock factor binding and chromosomal puffing, but does not induce hsp 70 gene transcription in Drosophila.
  Winegarden NA, Wong KS, Sopta M, Westwood JT. Winegarden NA, et al. J Biol Chem. 1996 Oct 25;271(43):26971-80. doi: 10.1074/jbc.271.43.26971. J Biol Chem. 1996. PMID: 8900183
• Sodium salicylate and yeast heat shock gene transcription.
  Giardina C, Lis JT. Giardina C, et al. J Biol Chem. 1995 May 5;270(18):10369-72. doi: 10.1074/jbc.270.18.10369. J Biol Chem. 1995. PMID: 7737966
• Heat shock factor and the heat shock response.
  Sorger PK. Sorger PK. Cell. 1991 May 3;65(3):363-6. doi: 10.1016/0092-8674(91)90452-5. Cell. 1991. PMID: 2018972 Review. No abstract available.
• [Regulation of heat shock gene expression in response to stress].
  Garbuz DG. Garbuz DG. Mol Biol (Mosk). 2017 May-Jun;51(3):400-417. doi: 10.7868/S0026898417020100. Mol Biol (Mosk). 2017. PMID: 28707656 Review. Russian.

Cited by

• Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication.
  Pauciullo S, Riccio A, Santopolo S, Albecka A, Papa G, James LC, Piacentini S, Lanzilli G, Rossi A, Santoro MG. Pauciullo S, et al. Cell Mol Life Sci. 2024 Sep 7;81(1):386. doi: 10.1007/s00018-024-05370-5. Cell Mol Life Sci. 2024. PMID: 39243335 Free PMC article.
• Role of heat shock proteins in aging and chronic inflammatory diseases.
  Gomez CR. Gomez CR. Geroscience. 2021 Oct;43(5):2515-2532. doi: 10.1007/s11357-021-00394-2. Epub 2021 Jul 9. Geroscience. 2021. PMID: 34241808 Free PMC article. Review.
• Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice.
  Trivedi R, Knopf B, Tripathi JK, Rakoczy S, Manocha GD, Brown-Borg H, Jurivich DA. Trivedi R, et al. Geroscience. 2021 Aug;43(4):1921-1934. doi: 10.1007/s11357-021-00362-w. Epub 2021 Apr 13. Geroscience. 2021. PMID: 33846884 Free PMC article.
• Multifactorial Attenuation of the Murine Heat Shock Response With Age.
  Jurivich DA, Manocha GD, Trivedi R, Lizakowski M, Rakoczy S, Brown-Borg H. Jurivich DA, et al. J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1846-1852. doi: 10.1093/gerona/glz204. J Gerontol A Biol Sci Med Sci. 2020. PMID: 31612204 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon