Epigenetics and cancer - PubMed (original) (raw)
Review
. 2004 Oct 1;18(19):2315-35.
doi: 10.1101/gad.1232504.
Affiliations
- PMID: 15466484
- DOI: 10.1101/gad.1232504
Free article
Review
Epigenetics and cancer
Anders H Lund et al. Genes Dev. 2004.
Free article
Abstract
Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional regulation locally and globally via modifications of the DNA and by modification or rearrangement of nucleosomes. Epigenetic gene regulation collaborates with genetic alterations in cancer development. This is evident from every aspect of tumor biology including cell growth and differentiation, cell cycle control, DNA repair, angiogenesis, migration, and evasion of host immunosurveillance. In contrast to genetic cancer causes, the possibility of reversing epigenetic codes may provide new targets for therapeutic intervention.
Copyright 2004 Cold Spring Harbor Laboratory Press
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