A focus on the synapse for neuroprotection in Alzheimer disease and other dementias - PubMed (original) (raw)
Review
A focus on the synapse for neuroprotection in Alzheimer disease and other dementias
Paul Coleman et al. Neurology. 2004.
Abstract
Synaptic dysfunction and failure are processes that occur early in Alzheimer disease (AD) and are important targets for protective treatments to slow AD progression and preserve cognitive and functional abilities. Synaptic loss is the best current pathologic correlate of cognitive decline, and synaptic dysfunction is evident long before synapses and neurons are lost. Once synaptic function fails, even in the setting of surviving neurons, there may be little chance of effectively interfering with the disease process. This review emphasizes the importance of preserving synaptic structure and function (i.e., "synaptoprotection") in AD. Such "synaptoprotective" therapy will probably need to be administered at a critical early time point, perhaps years before onset of clinical symptoms.
Comment in
- A focus on the synapse for neuroprotection in Alzheimer disease and other dementias.
Brenner SR. Brenner SR. Neurology. 2005 Jun 14;64(11):1991; author reply 1991. doi: 10.1212/wnl.64.11.1991. Neurology. 2005. PMID: 15955973 No abstract available.
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