Education and the course of cognitive decline in Alzheimer disease - PubMed (original) (raw)
Education and the course of cognitive decline in Alzheimer disease
R S Wilson et al. Neurology. 2004.
Abstract
Objective: To test the hypothesis that higher level of education is related to more rapid cognitive decline in Alzheimer disease (AD).
Methods: Participants are older persons with clinically diagnosed AD recruited from health care facilities in the Chicago area. At 6-month intervals for up to 4 years, they underwent uniform structured clinical evaluations that included administration of nine cognitive performance tests from which a composite measure of global cognition was derived. Analyses are based on 494 persons with follow-up data (89.3% of those eligible). In mixed models that allowed for linear and nonlinear decline, the authors first accounted for the effects of age on cognition and then tested the relation of education to rate of cognitive decline.
Results: Global cognitive decline had linear and nonlinear components, resulting in a gradually accelerating course of decline. Age was related to linear but not nonlinear decline, with more rapid decline observed in younger compared with older persons. Higher educational level was related to more rapid global cognitive decline, as hypothesized, with education related to the nonlinear but not the linear component of decline.
Conclusion: Higher educational attainment is associated with a slightly accelerated rate of cognitive decline in Alzheimer disease.
Similar articles
- Educational attainment and cognitive decline in old age.
Wilson RS, Hebert LE, Scherr PA, Barnes LL, Mendes de Leon CF, Evans DA. Wilson RS, et al. Neurology. 2009 Feb 3;72(5):460-5. doi: 10.1212/01.wnl.0000341782.71418.6c. Neurology. 2009. PMID: 19188578 Free PMC article. - Nursing home placement, day care use, and cognitive decline in Alzheimer's disease.
Wilson RS, McCann JJ, Li Y, Aggarwal NT, Gilley DW, Evans DA. Wilson RS, et al. Am J Psychiatry. 2007 Jun;164(6):910-5. doi: 10.1176/ajp.2007.164.6.910. Am J Psychiatry. 2007. PMID: 17541050 - Change in cognitive function in older persons from a community population: relation to age and Alzheimer disease.
Wilson RS, Beckett LA, Bennett DA, Albert MS, Evans DA. Wilson RS, et al. Arch Neurol. 1999 Oct;56(10):1274-9. doi: 10.1001/archneur.56.10.1274. Arch Neurol. 1999. PMID: 10520945 - Education modifies the relation of AD pathology to level of cognitive function in older persons.
Bennett DA, Wilson RS, Schneider JA, Evans DA, Mendes de Leon CF, Arnold SE, Barnes LL, Bienias JL. Bennett DA, et al. Neurology. 2003 Jun 24;60(12):1909-15. doi: 10.1212/01.wnl.0000069923.64550.9f. Neurology. 2003. PMID: 12821732 - Insulin resistance, cognition, and Alzheimer disease.
Kim AB, Arvanitakis Z. Kim AB, et al. Obesity (Silver Spring). 2023 Jun;31(6):1486-1498. doi: 10.1002/oby.23761. Obesity (Silver Spring). 2023. PMID: 37203336 Free PMC article. Review.
Cited by
- Statistical Disease Progression Modeling in Alzheimer Disease.
Raket LL. Raket LL. Front Big Data. 2020 Aug 12;3:24. doi: 10.3389/fdata.2020.00024. eCollection 2020. Front Big Data. 2020. PMID: 33693397 Free PMC article. - Prognosis of Early-Onset vs. Late-Onset Mild Cognitive Impairment: Comparison of Conversion Rates and Its Predictors.
Tábuas-Pereira M, Baldeiras I, Duro D, Santiago B, Ribeiro MH, Leitão MJ, Oliveira C, Santana I. Tábuas-Pereira M, et al. Geriatrics (Basel). 2016 Apr 25;1(2):11. doi: 10.3390/geriatrics1020011. Geriatrics (Basel). 2016. PMID: 31022805 Free PMC article. - Cognitive decline in patients with Alzheimer's disease and its related factors in a memory clinic setting, Shanghai, China.
Zhao Q, Zhou B, Ding D, Teramukai S, Guo Q, Fukushima M, Hong Z. Zhao Q, et al. PLoS One. 2014 Apr 21;9(4):e95755. doi: 10.1371/journal.pone.0095755. eCollection 2014. PLoS One. 2014. PMID: 24752600 Free PMC article. - Brain Insulin Signaling is Associated with Late-Life Cognitive Decline.
Tong H, Capuano AW, Carmichael OT, Gwizdala KL, Bennett DA, Ahima RS, Arnold SE, Arvanitakis Z. Tong H, et al. Aging Dis. 2024 Oct 1;15(5):2205-2215. doi: 10.14336/AD.2023.1117. Aging Dis. 2024. PMID: 38029396 Free PMC article. - Correlates of depressive symptoms in rural elderly Chinese.
Gao S, Jin Y, Unverzagt FW, Liang C, Hall KS, Ma F, Murrell JR, Cheng Y, Matesan J, Li P, Bian J, Hendrie HC. Gao S, et al. Int J Geriatr Psychiatry. 2009 Dec;24(12):1358-66. doi: 10.1002/gps.2271. Int J Geriatr Psychiatry. 2009. PMID: 19347839 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical