Retinoic acid imprints gut-homing specificity on T cells - PubMed (original) (raw)
Retinoic acid imprints gut-homing specificity on T cells
Makoto Iwata et al. Immunity. 2004 Oct.
Free article
Abstract
For a preferential homing of T cells to the gut, expression of the integrin alpha4beta7 and the chemokine receptor CCR9 is essential and is induced by antigenic stimulation with dendritic cells from the gut-associated lymphoid organs. Here, we show that the vitamin A (retinol) metabolite, retinoic acid, enhances the expression of alpha4beta7 and CCR9 on T cells upon activation and imprints them with the gut tropism. Dendritic cells from the gut-associated lymphoid organs produced retinoic acid from retinol. The enhanced alpha4beta7 expression on T cells by antigenic stimulation with these dendritic cells was suppressed by the retinal dehydrogenase inhibitor citral and the retinoic acid receptor antagonist LE135. Accordingly, vitamin A deficiency caused a reduction in alpha4beta7(+) memory/activated T cells in lymphoid organs and a depletion of T cells from the intestinal lamina propria. These findings revealed a novel role for retinoic acid in the imprinting of gut-homing specificity on T cells.
Comment in
- Retinoic acid: an educational "vitamin elixir" for gut-seeking T cells.
Mora JR, von Andrian UH. Mora JR, et al. Immunity. 2004 Oct;21(4):458-60. doi: 10.1016/j.immuni.2004.10.002. Immunity. 2004. PMID: 15485623
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