For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion - PubMed (original) (raw)
For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion
Kevin N Ochsner et al. Neuroimage. 2004 Oct.
Abstract
Functional neuroimaging studies examining the neural bases of the cognitive control of emotion have found increased prefrontal and decreased amygdala activation for the reduction or down-regulation of negative emotion. It is unknown, however, (1) whether the same neural systems underlie the enhancement or up-regulation of emotion, and (2) whether altering the nature of the regulatory strategy alters the neural systems mediating the regulation. To address these questions using functional magnetic resonance imaging (fMRI), participants up- and down-regulated negative emotion either by focusing internally on the self-relevance of aversive scenes or by focusing externally on alternative meanings for pictured actions and their situational contexts. Results indicated (1a) that both up- and down-regulating negative emotion recruited prefrontal and anterior cingulate regions implicated in cognitive control, (1b) that amygdala activation was modulated up or down in accord with the regulatory goal, and (1c) that up-regulation uniquely recruited regions of left rostromedial PFC implicated in the retrieval of emotion knowledge, whereas down-regulation uniquely recruited regions of right lateral and orbital PFC implicated in behavioral inhibition. Results also indicated that (2) self-focused regulation recruited medial prefrontal regions implicated in internally focused processing, whereas situation-focused regulation recruited lateral prefrontal regions implicated in externally focused processing. These data suggest that both common and distinct neural systems support various forms of reappraisal and that which particular prefrontal systems modulate the amygdala in different ways depends on the regulatory goal and strategy employed.
Similar articles
- Rethinking feelings: an FMRI study of the cognitive regulation of emotion.
Ochsner KN, Bunge SA, Gross JJ, Gabrieli JD. Ochsner KN, et al. J Cogn Neurosci. 2002 Nov 15;14(8):1215-29. doi: 10.1162/089892902760807212. J Cogn Neurosci. 2002. PMID: 12495527 - Neural correlates of positive and negative emotion regulation.
Kim SH, Hamann S. Kim SH, et al. J Cogn Neurosci. 2007 May;19(5):776-98. doi: 10.1162/jocn.2007.19.5.776. J Cogn Neurosci. 2007. PMID: 17488204 - Cognitive modulation of emotion anticipation.
Erk S, Abler B, Walter H. Erk S, et al. Eur J Neurosci. 2006 Aug;24(4):1227-36. doi: 10.1111/j.1460-9568.2006.04976.x. Eur J Neurosci. 2006. PMID: 16930447 - The cognitive control of emotion.
Ochsner KN, Gross JJ. Ochsner KN, et al. Trends Cogn Sci. 2005 May;9(5):242-9. doi: 10.1016/j.tics.2005.03.010. Trends Cogn Sci. 2005. PMID: 15866151 Review. - Fear is only as deep as the mind allows: a coordinate-based meta-analysis of neuroimaging studies on the regulation of negative affect.
Diekhof EK, Geier K, Falkai P, Gruber O. Diekhof EK, et al. Neuroimage. 2011 Sep 1;58(1):275-85. doi: 10.1016/j.neuroimage.2011.05.073. Epub 2011 Jun 6. Neuroimage. 2011. PMID: 21669291 Review.
Cited by
- Brain activity associated with emotion regulation predicts individual differences in working memory ability.
Horner SB, Lulla R, Wu H, Shaktivel S, Vaccaro A, Herschel E, Christov-Moore L, McDaniel C, Kaplan JT, Greening SG. Horner SB, et al. Cogn Affect Behav Neurosci. 2024 Oct 8. doi: 10.3758/s13415-024-01232-6. Online ahead of print. Cogn Affect Behav Neurosci. 2024. PMID: 39379769 - Relationship of prefrontal cortex activity with anhedonia and cognitive function in major depressive disorder: an fNIRS study.
Fan H, Li Q, Du Y, Yan Y, Ni R, Wei J, Zhao L, Yang X, Ma X. Fan H, et al. Front Psychiatry. 2024 Sep 19;15:1428425. doi: 10.3389/fpsyt.2024.1428425. eCollection 2024. Front Psychiatry. 2024. PMID: 39371911 Free PMC article. - The Effects of Parental Emotion Regulation Ability on Parenting Self-Efficacy and Child Diet.
Sagui-Henson SJ, Armstrong LM, Mitchell AD, Basquin CA, Levens SM. Sagui-Henson SJ, et al. J Child Fam Stud. 2020 Aug;29(8):2290-2302. doi: 10.1007/s10826-020-01745-x. Epub 2020 Jun 24. J Child Fam Stud. 2020. PMID: 39211308 Free PMC article. - Independent replications reveal anterior and posterior cingulate cortex activation underlying state anxiety-attenuated face encoding.
Buehler SK, Lowther M, Lukow PB, Kirk PA, Pike AC, Yamamori Y, Chavanne AV, Gormley S, Goble T, Tuominen EW, Aylward J, McCloud T, Rodriguez-Sanchez J, Robinson OJ. Buehler SK, et al. Commun Psychol. 2024 Aug 24;2:80. doi: 10.1038/s44271-024-00128-y. eCollection 2024. Commun Psychol. 2024. PMID: 39184223 Free PMC article. - Theta oscillations underlie the interplay between emotional processing and empathy.
Romeo Z, Spironelli C. Romeo Z, et al. Heliyon. 2024 Jul 19;10(14):e34581. doi: 10.1016/j.heliyon.2024.e34581. eCollection 2024 Jul 30. Heliyon. 2024. PMID: 39148968 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous