Lipid rafts clustering and signalling by listeriolysin O - PubMed (original) (raw)
Review
. 2004 Nov;32(Pt 5):712-4.
doi: 10.1042/BST0320712.
Affiliations
- PMID: 15493995
- DOI: 10.1042/BST0320712
Review
Lipid rafts clustering and signalling by listeriolysin O
N O Gekara et al. Biochem Soc Trans. 2004 Nov.
Abstract
Listeriolysin O, the major virulent determinant of Listeria monocytogenes, is known for forming pores on cholesterol-rich membranes. In the present study, we reveal its other facet, rafts clustering. By immunofluorescence microscopy, we show that the glycosylphosphatidylinositol-anchored proteins CD14 and CD24, which normally exhibit uniform distribution on J774 cells, undergo clustering upon treatment with LLO. The non-raft marker transferrin receptor is unaffected by such treatment. Rafts clustering might explain the induction of tyrosine phosphorylation observed on LLO-treated cells.
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