Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes - PubMed (original) (raw)

. 2004 Oct;68(10):2178-82.

doi: 10.1271/bbb.68.2178.

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• PMID: 15502365
• DOI: 10.1271/bbb.68.2178

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Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes

Hajime Motoyoshi et al. Biosci Biotechnol Biochem. 2004 Oct.

Free article

Abstract

The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate the binding proteins.

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