Contribution of inherited factors to rheumatoid arthritis - PubMed (original) (raw)
Contribution of inherited factors to rheumatoid arthritis
C M Deighton et al. Ann Rheum Dis. 1992 Feb.
Abstract
A total of 231 sibships of the same sex (186 female, 45 male), in which the proband had classical or definite rheumatoid arthritis (RA) have been selected from rheumatology clinics. Each sibship member was questioned about symptomatic joints, which were then examined. Hospital records, radiographs, and rheumatoid factor measurements allowed each sibling to be classified as having classical, definite, probable, or no RA. Each sibling was typed for HLA-A and B and was classified as sharing two, one, or zero HLA haplotypes with the proband. Concordance rates for classical and definite RA were three times greater in sibships of women than of men (9.3 v 3.0%). Concordance rates in HLA identical sibships were twice those in hemi- and non-identical sibships (15.5, 7.1, and 5.2%, respectively). Probable RA was more common in male and HLA hemi- and non-identical sibships. These results suggest that female sex and the two inherited HLA haplotypes are important for the presence and expression of RA. Although environmental factors may be shared more in twins than siblings, a concordance rate of 20.5% in seropositive HLA identical sibships of the same sex compared with 30% in monozygotic twins suggests that sex and HLA type account for about two thirds of the inherited risk of RA.
Similar articles
- Linkage of rheumatoid arthritis with HLA.
Deighton CM, Kelly PJ, Walker DJ. Deighton CM, et al. Ann Rheum Dis. 1993 Sep;52(9):638-42. doi: 10.1136/ard.52.9.638. Ann Rheum Dis. 1993. PMID: 8239757 Free PMC article. - Rheumatoid arthritis in thyroid disease positive and negative same-sexed sibships.
Deighton CM, Fay A, Walker DJ. Deighton CM, et al. Br J Rheumatol. 1992 Jan;31(1):13-7. doi: 10.1093/rheumatology/31.1.13. Br J Rheumatol. 1992. PMID: 1730099 - HLA haplotype sharing in rheumatoid arthritis sibships: risk estimates in siblings.
Rigby AS. Rigby AS. Scand J Rheumatol. 1992;21(2):68-73. doi: 10.3109/03009749209095070. Scand J Rheumatol. 1992. PMID: 1570492 - The contribution of HLA to rheumatoid arthritis.
Deighton CM, Walker DJ, Griffiths ID, Roberts DF. Deighton CM, et al. Clin Genet. 1989 Sep;36(3):178-82. doi: 10.1111/j.1399-0004.1989.tb03185.x. Clin Genet. 1989. PMID: 2676268 Review. - Rheumatoid arthritis: inheritance and association with other autoimmune diseases.
Grennan DM, Sanders PA, Thomson W, Dyer PA. Grennan DM, et al. Dis Markers. 1986 Jun;4(1-2):157-62. Dis Markers. 1986. PMID: 3330697 Review.
Cited by
- Secretory antibodies to citrullinated peptides in plasma and saliva from rheumatoid arthritis patients and their unaffected first-degree relatives.
Svärd A, Roos Ljungberg K, Brink M, Martinsson K, Sjöwall C, Rantapää Dahlqvist S, Kastbom A. Svärd A, et al. Clin Exp Immunol. 2020 Feb;199(2):143-149. doi: 10.1111/cei.13381. Epub 2019 Oct 22. Clin Exp Immunol. 2020. PMID: 31605388 Free PMC article. Clinical Trial. - Modulation of autoimmune arthritis by environmental 'hygiene' and commensal microbiota.
Langan D, Kim EY, Moudgil KD. Langan D, et al. Cell Immunol. 2019 May;339:59-67. doi: 10.1016/j.cellimm.2018.12.005. Epub 2018 Dec 10. Cell Immunol. 2019. PMID: 30638679 Free PMC article. Review. - Family history of rheumatoid arthritis: an old concept with new developments.
Frisell T, Saevarsdottir S, Askling J. Frisell T, et al. Nat Rev Rheumatol. 2016 Jun;12(6):335-43. doi: 10.1038/nrrheum.2016.52. Epub 2016 Apr 21. Nat Rev Rheumatol. 2016. PMID: 27098907 Review. - Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking.
Scott IC, Seegobin SD, Steer S, Tan R, Forabosco P, Hinks A, Eyre S, Morgan AW, Wilson AG, Hocking LJ, Wordsworth P, Barton A, Worthington J, Cope AP, Lewis CM. Scott IC, et al. PLoS Genet. 2013;9(9):e1003808. doi: 10.1371/journal.pgen.1003808. Epub 2013 Sep 19. PLoS Genet. 2013. PMID: 24068971 Free PMC article. - Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis.
Young KA, Deane KD, Derber LA, Hughes-Austin JM, Wagner CA, Sokolove J, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, Norris JM. Young KA, et al. Arthritis Rheum. 2013 Aug;65(8):1995-2004. doi: 10.1002/art.38022. Arthritis Rheum. 2013. PMID: 23754702 Free PMC article.
References
- J Rheumatol. 1988 Jul;15(7):1050-3 - PubMed
- Arthritis Rheum. 1988 Mar;31(3):315-24 - PubMed
- Bull Rheum Dis. 1958 Dec;9(4):175-6 - PubMed
- J Rheumatol. 1988 Aug;15(8):1189-92 - PubMed
- Clin Genet. 1989 Sep;36(3):178-82 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials