Context memories and reactivation: constraints on the reconsolidation hypothesis - PubMed (original) (raw)
Comparative Study
. 2004 Oct;118(5):956-64.
doi: 10.1037/0735-7044.118.5.956.
Affiliations
- PMID: 15506878
- DOI: 10.1037/0735-7044.118.5.956
Comparative Study
Context memories and reactivation: constraints on the reconsolidation hypothesis
Joseph C Biedenkapp et al. Behav Neurosci. 2004 Oct.
Abstract
Recent evidence suggests that the maintenance of a reactivated contextual-fear memory requires a protein-synthesis-dependent reconsolidation process in the hippocampus (K. Nader, 2003). In contrast, the authors report a systematic set of experiments that failed to find evidence that the rat's reactivated memory for context becomes labile and requires a new protein to restabilize. Although injecting the protein-synthesis inhibitor into the dorsal hippocampus or intracerebroventricularly following the reactivation of the context memory had no effect, these same treatments did impair the initial consolidation of the context memory and the consolidation of a contextual-fear memory. These results suggest that there may be important constraints determining when a reactivated memory requires reconsolidation. The authors offer 2 hypotheses about the nature of these constraints.
Copyright 2004 APA.
Similar articles
- Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval.
Nader K, Schafe GE, Le Doux JE. Nader K, et al. Nature. 2000 Aug 17;406(6797):722-6. doi: 10.1038/35021052. Nature. 2000. PMID: 10963596 - The amygdala modulates hippocampus-dependent context memory formation and stores cue-shock associations.
Huff NC, Rudy JW. Huff NC, et al. Behav Neurosci. 2004 Feb;118(1):53-62. doi: 10.1037/0735-7044.118.1.53. Behav Neurosci. 2004. PMID: 14979782 - Inhibition of hippocampal protein synthesis following recall disrupts expression of episodic-like memory in trace conditioning.
Runyan JD, Dash PK. Runyan JD, et al. Hippocampus. 2005;15(3):333-9. doi: 10.1002/hipo.20055. Hippocampus. 2005. PMID: 15523611 - Memory reconsolidation hypothesis revived but restrained: theoretical comment on Biedenkapp and Rudy (2004).
McGaugh JL. McGaugh JL. Behav Neurosci. 2004 Oct;118(5):1140-2. doi: 10.1037/0735-7044.118.5.1140. Behav Neurosci. 2004. PMID: 15506899 Review. - The labile nature of consolidation theory.
Nader K, Schafe GE, LeDoux JE. Nader K, et al. Nat Rev Neurosci. 2000 Dec;1(3):216-9. doi: 10.1038/35044580. Nat Rev Neurosci. 2000. PMID: 11257912 Review.
Cited by
- Lack of drug-induced post-retrieval amnesia for auditory fear memories in rats.
Luyten L, Schnell AE, Schroyens N, Beckers T. Luyten L, et al. BMC Biol. 2021 Jan 26;19(1):17. doi: 10.1186/s12915-021-00957-x. BMC Biol. 2021. PMID: 33499865 Free PMC article. - Contextual processing elicits sex differences in dorsal hippocampus activation following footshock and context fear retrieval.
Colon LM, Poulos AM. Colon LM, et al. Behav Brain Res. 2020 Sep 1;393:112771. doi: 10.1016/j.bbr.2020.112771. Epub 2020 Jun 16. Behav Brain Res. 2020. PMID: 32561387 Free PMC article. - Reconsolidation: maintaining memory relevance.
Lee JL. Lee JL. Trends Neurosci. 2009 Aug;32(8):413-20. doi: 10.1016/j.tins.2009.05.002. Epub 2009 Jul 27. Trends Neurosci. 2009. PMID: 19640595 Free PMC article. - GSK-3β and memory formation.
Takashima A. Takashima A. Front Mol Neurosci. 2012 Apr 23;5:47. doi: 10.3389/fnmol.2012.00047. eCollection 2012. Front Mol Neurosci. 2012. PMID: 22536172 Free PMC article. - Differential expression of the immediate early genes c-Fos, Arc, Egr-1, and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE).
Heroux NA, Osborne BF, Miller LA, Kawan M, Buban KN, Rosen JB, Stanton ME. Heroux NA, et al. Neurobiol Learn Mem. 2018 Jan;147:128-138. doi: 10.1016/j.nlm.2017.11.016. Epub 2017 Dec 6. Neurobiol Learn Mem. 2018. PMID: 29222058 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical