Programmed -1 ribosomal frameshifting in the SARS coronavirus - PubMed (original) (raw)
. 2004 Dec;32(Pt 6):1081-3.
doi: 10.1042/BST0321081.
Affiliations
- PMID: 15506971
- DOI: 10.1042/BST0321081
Programmed -1 ribosomal frameshifting in the SARS coronavirus
F Dos Ramos et al. Biochem Soc Trans. 2004 Dec.
Abstract
Programmed -1 ribosomal frameshifting is an alternate mechanism of translation used by coronavirus to synthesize replication proteins encoded by two overlapping open reading frames. For some coronaviruses, the mRNA cis-acting stimulatory structures involved in this process have been characterized, but their precise contribution to ribosomal frameshifting is not completely understood. Recently, a novel coronavirus was identified as the causative agent of the severe acute respiratory syndrome. This review describes the mRNA motifs involved in programmed -1 ribosomal frameshifting in this virus.
Similar articles
- Achieving a golden mean: mechanisms by which coronaviruses ensure synthesis of the correct stoichiometric ratios of viral proteins.
Plant EP, Rakauskaite R, Taylor DR, Dinman JD. Plant EP, et al. J Virol. 2010 May;84(9):4330-40. doi: 10.1128/JVI.02480-09. Epub 2010 Feb 17. J Virol. 2010. PMID: 20164235 Free PMC article. - A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal.
Plant EP, Pérez-Alvarado GC, Jacobs JL, Mukhopadhyay B, Hennig M, Dinman JD. Plant EP, et al. PLoS Biol. 2005 Jun;3(6):e172. doi: 10.1371/journal.pbio.0030172. Epub 2005 May 17. PLoS Biol. 2005. PMID: 15884978 Free PMC article. - The role of programmed-1 ribosomal frameshifting in coronavirus propagation.
Plant EP, Dinman JD. Plant EP, et al. Front Biosci. 2008 May 1;13:4873-81. doi: 10.2741/3046. Front Biosci. 2008. PMID: 18508552 Free PMC article. Review. - Programmed ribosomal frameshifting in decoding the SARS-CoV genome.
Baranov PV, Henderson CM, Anderson CB, Gesteland RF, Atkins JF, Howard MT. Baranov PV, et al. Virology. 2005 Feb 20;332(2):498-510. doi: 10.1016/j.virol.2004.11.038. Virology. 2005. PMID: 15680415 Free PMC article. - Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV.
Brierley I, Dos Ramos FJ. Brierley I, et al. Virus Res. 2006 Jul;119(1):29-42. doi: 10.1016/j.virusres.2005.10.008. Epub 2005 Nov 28. Virus Res. 2006. PMID: 16310880 Free PMC article. Review.
Cited by
- Possible involvement of three-stemmed pseudoknots in regulating translational initiation in human mRNAs.
Huang X, Du Z. Huang X, et al. PLoS One. 2024 Jul 22;19(7):e0307541. doi: 10.1371/journal.pone.0307541. eCollection 2024. PLoS One. 2024. PMID: 39038036 Free PMC article. - Iron‑sulfur clusters in viral proteins: Exploring their elusive nature, roles and new avenues for targeting infections.
Maio N, Heffner AL, Rouault TA. Maio N, et al. Biochim Biophys Acta Mol Cell Res. 2024 Jun;1871(5):119723. doi: 10.1016/j.bbamcr.2024.119723. Epub 2024 Apr 8. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 38599324 Review. - Elaborated pseudoknots that stimulate -1 programmed ribosomal frameshifting or stop codon readthrough in RNA viruses.
Huang X, Du Z. Huang X, et al. J Biomol Struct Dyn. 2023 Dec 14:1-13. doi: 10.1080/07391102.2023.2292296. Online ahead of print. J Biomol Struct Dyn. 2023. PMID: 38095458 - Mechanisms of Coronavirus Genome Stability As Potential Targets for Antiviral Drugs.
Yuyukina SK, Zharkov DO. Yuyukina SK, et al. Her Russ Acad Sci. 2022;92(4):470-478. doi: 10.1134/S1019331622040256. Epub 2022 Sep 6. Her Russ Acad Sci. 2022. PMID: 36091852 Free PMC article. - Viral and cellular translation during SARS-CoV-2 infection.
Eriani G, Martin F. Eriani G, et al. FEBS Open Bio. 2022 Sep;12(9):1584-1601. doi: 10.1002/2211-5463.13413. Epub 2022 Apr 25. FEBS Open Bio. 2022. PMID: 35429230 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous