Hallmarks of 'BRCAness' in sporadic cancers - PubMed (original) (raw)

Review

doi: 10.1038/nrc1457.

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• PMID: 15510162
• DOI: 10.1038/nrc1457

Review

Hallmarks of 'BRCAness' in sporadic cancers

Nicholas Turner et al. Nat Rev Cancer. 2004 Oct.

Abstract

Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer susceptibility, and the proteins encoded by these genes have distinct functions in related DNA-repair processes. Emerging evidence indicates that these processes are disrupted by numerous mechanisms in sporadic cancers. Collectively, there are properties that define 'BRCAness' - that is, traits that some sporadic cancers share with those occurring in either BRCA1- or BRCA2-mutation carriers. These common properties might have important implications for the clinical management of these cancers.

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