Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice - PubMed (original) (raw)

. 2004 Oct 29;306(5697):879-81.

doi: 10.1126/science.1101678.

Affiliations

• PMID: 15514160
• DOI: 10.1126/science.1101678

Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice

Mark S Ansorge et al. Science. 2004.

Abstract

Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown. Transient inhibition of 5-HTT during early development with fluoxetine, a commonly used serotonin selective reuptake inhibitor, produced abnormal emotional behaviors in adult mice. This effect mimicked the behavioral phenotype of mice genetically deficient in 5-HTT expression. These findings indicate a critical role of serotonin in the maturation of brain systems that modulate emotional function in the adult and suggest a developmental mechanism to explain how low-expressing 5-HTT promoter alleles increase vulnerability to psychiatric disorders.

PubMed Disclaimer

Comment in

• Neuroscience. Prozac treatment of newborn mice raises anxiety.
  Holden C. Holden C. Science. 2004 Oct 29;306(5697):792. doi: 10.1126/science.306.5697.792. Science. 2004. PMID: 15514122 No abstract available.

Similar articles

• Neuroscience. Prozac treatment of newborn mice raises anxiety.
  Holden C. Holden C. Science. 2004 Oct 29;306(5697):792. doi: 10.1126/science.306.5697.792. Science. 2004. PMID: 15514122 No abstract available.
• Inhibition of the serotonin (5-hydroxytryptamine) transporter reduces bone accrual during growth.
  Warden SJ, Robling AG, Sanders MS, Bliziotes MM, Turner CH. Warden SJ, et al. Endocrinology. 2005 Feb;146(2):685-93. doi: 10.1210/en.2004-1259. Epub 2004 Nov 11. Endocrinology. 2005. PMID: 15539550
• (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter.
  Ni W, Wilhelm CS, Bader M, Murphy DL, Lookingland K, Watts SW. Ni W, et al. J Pharmacol Exp Ther. 2005 Sep;314(3):953-60. doi: 10.1124/jpet.105.087080. Epub 2005 May 18. J Pharmacol Exp Ther. 2005. PMID: 15901794
• Cocaine, reward, movement and monoamine transporters.
  Uhl GR, Hall FS, Sora I. Uhl GR, et al. Mol Psychiatry. 2002;7(1):21-6. doi: 10.1038/sj.mp.4000964. Mol Psychiatry. 2002. PMID: 11803442 Review.
• Genetic perspectives on the serotonin transporter.
  Murphy DL, Li Q, Engel S, Wichems C, Andrews A, Lesch KP, Uhl G. Murphy DL, et al. Brain Res Bull. 2001 Nov 15;56(5):487-94. doi: 10.1016/s0361-9230(01)00622-0. Brain Res Bull. 2001. PMID: 11750794 Review.

Cited by

• Precision Medicine in Depression: The Role of Proteomics and Metabolomics in Personalized Treatment Approaches.
  Jaber M, Kahwaji H, Nasr S, Baz R, Kim YK, Fakhoury M. Jaber M, et al. Adv Exp Med Biol. 2024;1456:359-378. doi: 10.1007/978-981-97-4402-2_18. Adv Exp Med Biol. 2024. PMID: 39261438 Review.
• Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits.
  Soto NN, Gaspar P, Bacci A. Soto NN, et al. ACS Chem Neurosci. 2024 Apr 17;15(8):1611-1618. doi: 10.1021/acschemneuro.3c00828. Epub 2024 Apr 5. ACS Chem Neurosci. 2024. PMID: 38580316 Free PMC article. Review.
• Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons.
  Kisner A, Polter AM. Kisner A, et al. J Neurophysiol. 2024 Apr 1;131(4):626-637. doi: 10.1152/jn.00037.2023. Epub 2024 Feb 21. J Neurophysiol. 2024. PMID: 38380827 Free PMC article.
• Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex.
  Ogelman R, Gomez Wulschner LE, Hoelscher VM, Hwang IW, Chang VN, Oh WC. Ogelman R, et al. Nat Commun. 2024 Feb 16;15(1):1368. doi: 10.1038/s41467-024-45734-w. Nat Commun. 2024. PMID: 38365905 Free PMC article.
• Serotonergic Modulation of the Excitation/Inhibition Balance in the Visual Cortex.
  Carlos-Lima E, Higa GSV, Viana FJC, Tamais AM, Cruvinel E, Borges FDS, Francis-Oliveira J, Ulrich H, De Pasquale R. Carlos-Lima E, et al. Int J Mol Sci. 2023 Dec 30;25(1):519. doi: 10.3390/ijms25010519. Int J Mol Sci. 2023. PMID: 38203689 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations

• Medical

  • MedlinePlus Consumer Health Information
  • MedlinePlus Health Information