The nature of stem cells: state rather than entity - PubMed (original) (raw)
Review
doi: 10.1038/nrg1475.
Affiliations
- PMID: 15520797
- DOI: 10.1038/nrg1475
Review
The nature of stem cells: state rather than entity
Dov Zipori. Nat Rev Genet. 2004 Nov.
Abstract
Stem cells are endowed with self-renewal and multipotential differentiation capacities. Contrary to the expectation that stem cells would selectively express specific genes, these cells have a highly promiscuous gene-expression pattern. Here, I suggest that the transient stem cell state, termed the 'stem state', may be assumed by any cell and that the search for specific genes expressed by all stem cells, which would characterize the stem cell as a cell type, might be futile.
Similar articles
- Expression profile of an operationally-defined neural stem cell clone.
Parker MA, Anderson JK, Corliss DA, Abraria VE, Sidman RL, Park KI, Teng YD, Cotanche DA, Snyder EY. Parker MA, et al. Exp Neurol. 2005 Aug;194(2):320-32. doi: 10.1016/j.expneurol.2005.04.018. Exp Neurol. 2005. PMID: 15992799 - Design principle of gene expression used by human stem cells: implication for pluripotency.
Golan-Mashiach M, Dazard JE, Gerecht-Nir S, Amariglio N, Fisher T, Jacob-Hirsch J, Bielorai B, Osenberg S, Barad O, Getz G, Toren A, Rechavi G, Itskovitz-Eldor J, Domany E, Givol D. Golan-Mashiach M, et al. FASEB J. 2005 Jan;19(1):147-9. doi: 10.1096/fj.04-2417fje. Epub 2004 Oct 21. FASEB J. 2005. PMID: 15498892 - Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan.
Li SS, Liu YH, Tseng CN, Chung TL, Lee TY, Singh S. Li SS, et al. Stem Cells Dev. 2006 Aug;15(4):532-55. doi: 10.1089/scd.2006.15.532. Stem Cells Dev. 2006. PMID: 16978057 - Chipping away at 'stemness'.
Pyle AD, Donovan PJ, Lock LF. Pyle AD, et al. Genome Biol. 2004;5(8):235. doi: 10.1186/gb-2004-5-8-235. Epub 2004 Jul 29. Genome Biol. 2004. PMID: 15287966 Free PMC article. Review. - Guiding embryonic stem cells towards differentiation: lessons from molecular embryology.
Spagnoli FM, Hemmati-Brivanlou A. Spagnoli FM, et al. Curr Opin Genet Dev. 2006 Oct;16(5):469-75. doi: 10.1016/j.gde.2006.08.004. Epub 2006 Aug 17. Curr Opin Genet Dev. 2006. PMID: 16919445 Review.
Cited by
- Modeling relaxation experiments with a mechanistic model of gene expression.
Estavoyer M, Dufeu M, Ranson G, Lefort S, Voeltzel T, Maguer-Satta V, Gandrillon O, Lepoutre T. Estavoyer M, et al. BMC Bioinformatics. 2024 Aug 20;25(1):270. doi: 10.1186/s12859-024-05816-4. BMC Bioinformatics. 2024. PMID: 39164646 Free PMC article. - Understanding Cell Differentiation Through Single-Cell Approaches: Conceptual Challenges of the Systemic Approach.
Racine L, Paldi A. Racine L, et al. Methods Mol Biol. 2024;2745:163-176. doi: 10.1007/978-1-0716-3577-3_10. Methods Mol Biol. 2024. PMID: 38060185 - The Genes-Stemness-Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints.
Stella GM, Marchiò C, Bari E, Ferrarotti I, Bertuccio FR, Di Gennaro A, Abbott DM, Putignano P, Campo I, Torre ML, Corsico AG. Stella GM, et al. Int J Mol Sci. 2023 Feb 9;24(4):3496. doi: 10.3390/ijms24043496. Int J Mol Sci. 2023. PMID: 36834912 Free PMC article. Review. - Distinguishing between ante factum and post factum properties of animal cell lines and demonstrating their use in grouping ray-finned fish cell lines into invitromes.
Bols NC, Lee LEJ, Dowd GC. Bols NC, et al. In Vitro Cell Dev Biol Anim. 2023 Jan;59(1):41-62. doi: 10.1007/s11626-022-00744-0. Epub 2023 Jan 31. In Vitro Cell Dev Biol Anim. 2023. PMID: 36719554 Review. - Revisiting Epithelial Carcinogenesis.
Méndez-López LF. Méndez-López LF. Int J Mol Sci. 2022 Jul 4;23(13):7437. doi: 10.3390/ijms23137437. Int J Mol Sci. 2022. PMID: 35806442 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical