Qa-1 restriction of CD8+ suppressor T cells - PubMed (original) (raw)

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Qa-1 restriction of CD8+ suppressor T cells

Stefanie Sarantopoulos et al. J Clin Invest. 2004 Nov.

Abstract

There is increasing evidence that the immune response can be inhibited by several T cell subsets, including NK T cells, CD25+CD4+ T cells, and a subpopulation of CD8+ T cells. Animal model studies of multiple sclerosis have suggested an important role for suppressor CD8+ T cells in protection against disease recurrence and exacerbation. The molecular lynchpin of CD8+ suppressive activity is the murine MHC molecule Qa-1, termed HLA-E in humans. Here we summarize findings from work on Qa-1 that have begun to delineate suppressor CD8+ T cells and their mechanisms of action in the context of self tolerance and autoimmune disease.

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Figure 1

Figure 1

Engagement of Qa-1 by the TCR and by CD94/NKG2A. (A) Presentation of Qa-1–bacterial GroEL peptide by a DC following Salmonella infection to CD8+ T cells, where the receptor is a TCR, leads to CTL responses. (B) Presentation of Qa-1–self peptides by activated CD4+ T cells to CD8+ T cells, where the receptor is a TCR, leads to the development of Qa-1–restricted suppressor CD8+ T cells. (C) Engagement of CD94/NKG2A receptors on CD8+ T cells with a DC can inhibit either TCR-mediated CTL responses specific for Qa-1–foreign peptide ligands and/or TCR-mediated suppressive responses specific for Qa-1–self peptide ligands. This NKG2A-dependent interaction may regulate expression of suppressor or cytotoxic CD8+ T cells through inhibition of cellular activation or diminished AICD.

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References

    1. Cantor H. T-cell receptor crossreactivity and autoimmune disease. Adv. Immunol. 2000;75:209–233. - PubMed
    1. Goldrath AW, Bevan MJ. Selecting and maintaining a diverse T-cell repertoire. Nature. 1999;402:255–262. - PubMed
    1. Bouneaud C, Kourilsky P, Bousso P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity. 2000;13:829–840. - PubMed
    1. Slifka MK, et al. Preferential escape of subdominant CD8+ T cells during negative selection results in an altered antiviral T cell hierarchy. J. Immunol. 2003;170:1231–1239. - PubMed
    1. Kearney ER, Pape KA, Loh DY, Jenkins MK. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1994;1:327–339. - PubMed

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