MicroRNA binding sites in Arabidopsis class III HD-ZIP mRNAs are required for methylation of the template chromosome - PubMed (original) (raw)
MicroRNA binding sites in Arabidopsis class III HD-ZIP mRNAs are required for methylation of the template chromosome
Ning Bao et al. Dev Cell. 2004 Nov.
Free article
Abstract
Dominant mutations in the Arabidopsis PHABULOSA (PHB) and PHAVOLUTA (PHV) transcription factor genes cause transformation of abaxial to adaxial leaf fates by altering a microRNA complementary site present in processed PHB and PHV mRNAs but not in the corresponding genomic DNA. phb-1d mutants accumulate excess PHB transcript throughout the leaf primordium, indicating defective regulation of PHB transcript synthesis and/or stability. We show that PHB and PHV coding sequences are heavily methylated downstream of the microRNA complementary site in most wild-type plant cells and that methylation is reduced in phb-1d and phv-1d mutants. Decreased methylation is limited to the chromosome bearing the dominant mutant allele in phb-1d heterozygotes. Low levels of methylation are detected in wt PHB DNA isolated from undifferentiated tissues. These results suggest a model in which the microRNA interacts with nascent, newly processed PHB mRNA to alter chromatin of the corresponding PHB template DNA predominantly in differentiated cells.
Comment in
- MicroRNAs guide asymmetric DNA modifications guiding asymmetric organs.
Eshed Y, Bowman JL. Eshed Y, et al. Dev Cell. 2004 Nov;7(5):629-30. doi: 10.1016/j.devcel.2004.10.011. Dev Cell. 2004. PMID: 15525522
Similar articles
- MicroRNAs guide asymmetric DNA modifications guiding asymmetric organs.
Eshed Y, Bowman JL. Eshed Y, et al. Dev Cell. 2004 Nov;7(5):629-30. doi: 10.1016/j.devcel.2004.10.011. Dev Cell. 2004. PMID: 15525522 - Alteration of the shoot radial pattern in Arabidopsis thaliana by a gain-of-function allele of the class III HD-Zip gene INCURVATA4.
Ochando I, González-Reig S, Ripoll JJ, Vera A, Martínez-Laborda A. Ochando I, et al. Int J Dev Biol. 2008;52(7):953-61. doi: 10.1387/ijdb.072306io. Int J Dev Biol. 2008. PMID: 18956325 - Spatially restricted microRNA directs leaf polarity through ARGONAUTE1.
Kidner CA, Martienssen RA. Kidner CA, et al. Nature. 2004 Mar 4;428(6978):81-4. doi: 10.1038/nature02366. Nature. 2004. PMID: 14999284 - RNA-directed DNA methylation and Pol IVb in Arabidopsis.
Matzke M, Kanno T, Huettel B, Daxinger L, Matzke AJ. Matzke M, et al. Cold Spring Harb Symp Quant Biol. 2006;71:449-59. doi: 10.1101/sqb.2006.71.028. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381327 Review. - Class III HD-Zip gene regulation, the golden fleece of ARGONAUTE activity?
Bowman JL. Bowman JL. Bioessays. 2004 Sep;26(9):938-42. doi: 10.1002/bies.20103. Bioessays. 2004. PMID: 15351964 Review.
Cited by
- Role of miRNAs in sucrose stress response, reactive oxygen species, and anthocyanin biosynthesis in Arabidopsis thaliana.
Azad MF, Dawar P, Esim N, Rock CD. Azad MF, et al. Front Plant Sci. 2023 Nov 3;14:1278320. doi: 10.3389/fpls.2023.1278320. eCollection 2023. Front Plant Sci. 2023. PMID: 38023835 Free PMC article. - Advances in understanding epigenetic regulation of plant trichome development: a comprehensive review.
Dong Y, Li S, Wu H, Gao Y, Feng Z, Zhao X, Shan L, Zhang Z, Ren H, Liu X. Dong Y, et al. Hortic Res. 2023 Jul 19;10(9):uhad145. doi: 10.1093/hr/uhad145. eCollection 2023 Sep. Hortic Res. 2023. PMID: 37691965 Free PMC article. - Role of mi RNA in Phytoremediation of Heavy Metals and Metal Induced Stress Alleviation.
Talukder P, Saha A, Roy S, Ghosh G, Roy DD, Barua S. Talukder P, et al. Appl Biochem Biotechnol. 2023 Sep;195(9):5712-5729. doi: 10.1007/s12010-023-04599-3. Epub 2023 Jun 30. Appl Biochem Biotechnol. 2023. PMID: 37389725 Review. - Patho-epigenetics: histone deacetylases as targets of pathogens and therapeutics.
Schator D, Gomez-Valero L, Buchrieser C, Rolando M. Schator D, et al. Microlife. 2021 Nov 29;2:uqab013. doi: 10.1093/femsml/uqab013. eCollection 2021. Microlife. 2021. PMID: 37223249 Free PMC article. - What Do We Know about Barley miRNAs?
Volná A, Bartas M, Pečinka P, Špunda V, Červeň J. Volná A, et al. Int J Mol Sci. 2022 Nov 25;23(23):14755. doi: 10.3390/ijms232314755. Int J Mol Sci. 2022. PMID: 36499082 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources